Semin Arthritis Rheu: Link between pregnancy, childbirth and risk of rheumatoid arthritis

Through systematic literature evaluation and meta-analysis, the study determined whether pregnancy and childbirth were associated with rheumatoid arthritis (RA) and whether this effect was affected by the time that passed through pregnancy/childbirth, the number of pregnancies/births, and serological conditionsresearchers searched the Medline/EMBASE database (1946-2018) using terms such as "rheumatoid arthritis.mp" or "arthritis, rheumatoid/" and "pregnancy.mp" or "pregnancy/mp" or "pregnancy/" or "pregnancy/" (1946-2018)Include symacross/cohort studies that analyze the relationship between female pregnancy/birth and RA riskThe meta-analysis included studies that reported previous vsprevious vsRA effect data for women who had never been pregnant/delivered as ORs/RRs and their 95% confidence intervalDescriptive analysis of other associations (e.gthe number of pregnancies/births and risks)20 studies (from 626 articles) met the inclusion criteria, including 14 case-control studies (cases 4,799; 11,941 cases) and 6 cohort studies (cases 8,575; 2,368,439)There was no significant correlation between meta-analysis of ra risk sins reported on women who had never given birth (OR 0.91; 95% CI 0.80-1.04) and previous vswomen who had never been pregnant (RA 0.86; 95% CI 0.46-1.62) and had no significant correlationThere is no consistent evidence of a link between the number of pregnancies/births and the risk of RANo significant correlation was found between being in pregnancy or having just given birth and RA riskthis system evaluation does not support the claim that there is a link between pregnancy and childbirth and risk of RA