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Video: Jagged Peptides Solve Tissue Regeneration Conundrum
Source: TMDU Associate Professor Itsuki Ajioka
Researchers at Tokyo Medical and Dental University (TMDU) have developed a new material that utilizes serrated peptides as an extracellular matrix for regeneration of damaged tissue
Watch the video on YouTube: https:// home-grown physiological processes with man-made materials that mimic biological structures during wound healing has proven to be an enduring challenge
.
The main problem is modeling the appropriate functions to promote cell growth, and the oversimplification of frameworks that do not reflect complex interaction networks
In a study published this month in the journal Nature Communications, a research team at Tokyo Medical and Dental University (TMDU) developed a serrated peptide that executes the extracellular matrix (ECM) The basic function of ECM as an artificial ECM for regeneration of injured tissue
.
The ECM is a network of biomolecules that facilitate the control and coordination of various cellular events, such as adhesion, migration of signaling molecules and tissue repair
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It does this by binding and releasing secreted proteins, including growth factors that stimulate cell growth
"Due to their cell-adhesive properties and ability to degrade into chemically defined molecules, self-assembled hydrogels have great potential for clinical applications," said Itsuki Ajioka, senior author of the study
.
"However, it is difficult to combine binding and The ability to release secreted proteins
To this end, the researchers designed a jagged self-assembling peptide (JigSAP) that mimics the hydrophobic surface of the dovetail arrangement motif of the intracellular protein glycoprotein a
.
JigSAP formed a hydrogel with uniform distribution of nanofibers under physiological conditions
"We rationally designed JigSAP based on known structural motifs that undergo conformational transitions leading to the formation of nanofibers," explains senior collaborator Takahiro Muraoka from Tokyo University of Agricultural Science and Technology.
Aggregate proteins such as glycoprotein A.
” “Our characterization of JigSAP in an aqueous environment shows that a proper distribution of nanofibers in the hydrogel provides favorable properties that allow it to mimic the conditions of tissue repair.
required natural ECM function
In a mouse model of stroke, injections of JigSAP and vegf -- which stimulate the growth of new blood vessels -- showed enhanced blood vessel formation
.
In a test assessing motor skills in mice after treatment, the mice also showed some functional recovery after a week of treatment
"Because our technique simply requires the simple design of various proteins that will be integrated and released by JigSAP, this approach can be broadly applied to targeted drug delivery, tissue remodeling frameworks, and sustained protein release," Ajioka said
