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Selective estrogen receptor degrader (SERD) amcenestrant in breast cancer fails to meet primary endpoint

 Last Update: 2022-04-22
 Source: Internet
 Author: User

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Estrogen receptor (ER) plays an important role in gene transcription and proliferation in ER-positive breast cancer
.

Selective regulation of the ER has been a therapeutic target for this specific type of breast cancer for more than 30 years

breast cancer

Estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer is the most common type of breast cancer, accounting for 65% of breast cancer cases in women under the age of 50 and breast cancer cases in women 50 and older 75%
of .

Estrogen binds to the ER and stimulates receptor-regulated transcription, which in turn promotes tumor cell growth and proliferation

Sanofi today announced that a Phase II study of its experimental selective estrogen receptor degrader (SERD) amcenestrant failed to meet its primary endpoint of improving progression-free survival (PFS) in certain breast cancer patients
.

"Despite the disappointing results, we will continue to study the efficacy of amcenestrant in patients with early breast cancer with different tumor characteristics," said John Reed, head of research and development at Sanofi

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