Recently, the research team of Tang Gongli, a researcher at the Shanghai Institute of Organic Chemistry of the Chinese Academy of Sciences, has made new progress in the biosynthesis of the ribosomal peptide natural product Mae Chamycin A (MCM-A) produced in the marine thermoactinomycete YM3-251
Chinese Academy of Sciences With the advancement of genome sequencing and bioinformatics analysis technology, the biosynthesis of natural products has developed rapidly
MCM-A is a marine cyclic peptide natural product with significant anti-tumor activity discovered in 2005
In view of the instability of the precursor peptide in Bacillus subtilis, the knockout mutant strains did not provide more effective intermediates and modification information.
Combined with the detection of the fermentation broth intermediates of the gene knockout mutants and the results of E.
Experts said that this study not only explored the biosynthetic pathway of MCM-A, but also produced or discovered better biological activity and multiple thiazole/oxazole structures through combined biosynthesis and genome mining methods.
Related paper information: https://doi.
https://doi.
org/10.
1016/j.
chembiol.
2021.
08.
005
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