Scientists reveal the mechanism of broad-spectrum anti influenza virus of iron-based nano enzyme

On September 21, the international biomedical authoritative journal therapeutics online published the latest cooperation results of Peng Daxin, Professor of the school of veterinary medicine of Yangzhou University, and Gao Lizheng, Professor of the school of translational medicine They found and revealed the mechanism of the action of iron-based nano enzyme to inactivate influenza virus by simulating enzyme catalytic reaction, which is expected to provide a "new weapon" for influenza prevention and control Peng Daxin told China Science Daily that influenza A virus is a very important zoonotic pathogen, which can cause infection and disease of human and many animals, and is the main cause of influenza pandemic for many times Because influenza A virus has many subtypes and rapid variation, it often leads to vaccine failure or drug resistance Therefore, it is necessary to study and apply effective and broad-spectrum influenza control agents According to Gao Lizheng, the catalytic activity of nano enzyme is comparable to that of natural enzyme, but it is more stable than natural enzyme and has the advantages of multi-function and low cost In recent years, nano enzyme has become a hot spot of interdisciplinary research In this latest study, iron-based nano enzyme mainly mimics the activity of lipoxygenase, and can also inactivate influenza virus in neutral environment "This broadens the research field of nano enzyme, provides a new influenza prevention and control strategy, and has broad application prospects." Gao Lizheng said Qin Tao, the first author and associate professor of the paper, introduced that the mechanism is simply summarized as follows: after contacting with influenza virus particles, the iron-based nano enzyme can effectively catalyze the lipid peroxidation of the capsule membrane of the virus "bullet proof coat" through the enzymatic reaction, and the oxidation products will further disintegrate the cell infection sharp instrument hemagglutinin protein and neuraminidase protein embedded on the surface of the capsule membrane, leading to the structure and function of influenza virus The destruction of the virus makes the ability of virus invasion and replication lose, and finally realizes the function of virus inactivation "The core substrate of Fe based nanoenzyme targeted catalysis is the lipid capsule of influenza virus This structure is highly conserved in a variety of subtypes of influenza virus Therefore, the preparation can achieve a broad-spectrum anti influenza effect, and can efficiently inactivate 12 more current subtypes of influenza virus, such as H1N1, H5N1, h7n9, etc." Qin Tao further said It is reported that this achievement has applied for a national invention patent and is expected to be widely used in anti-virus masks, air filtration devices in high-risk places, etc in the future, it is also of great significance to block the spread of influenza virus among people, livestock and poultry This research work has been supported by national key research and development plan, National Natural Science Foundation, Jiangsu Natural Science Foundation, Collaborative Innovation Center for prevention and control of important animal diseases and zoonoses in Jiangsu Province, and Jiangsu superior discipline (BIOON Com)