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| Scientists reveal a new mechanism of colorectal cancer microenvironment T cell metabolism regulation |
Recently, Tong Xuemei's team from the Department of Biochemistry and Molecular Cell Biology, School of Basic Medicine, Shanghai Jiaotong University, revealed a new mechanism of glucose metabolism regulation in colorectal cancer infiltrating Treg cells.
Colorectal cancer (CRC) is the world's second most common malignant tumor and the third most fatal tumor.
To this end, the research team analyzed the single-cell sequencing data and found that colorectal cancer infiltrating Treg cells had enhanced glycolytic activity.
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Colorectal cancer immune checkpoint inhibitor therapy has shown good efficacy in patients with microsatellite instability subtypes with mismatch repair defects, and microsatellite stable subtypes, which account for 80% to 90% of colorectal cancer patients There is almost no response to tumor immunotherapy.
It is reported that the research was congratulated and highly praised by a letter from Professor Don Ayer, the discoverer of the MondoA gene and the University of Utah in the United States.
Related paper information: org/10.
org/10.
1053/j.
gastro.
2021.
04.
041" target="_blank">https://doi.
org/10.
1053/j.
gastro.
2021.
04.
041
