The team of Yao Xuebiao, Liu Xing, Zang Jianye and collaborators of the University of Science and Technology of China recently clarified the quality control mechanism of the renewal process of gastric epithelial cells, providing a unique targeted chemical biology technology for dynamic intervention of Helicobacter pylori-mediated inflammation-cancer transformation Strategy
The spindle is an important membraneless organelle that regulates the quality control of eukaryotic cell renewal.
Given that TIP60 is an important compartmentalization catalytic enzyme, studies suggest that mutations in the TIP60 signaling axis gene increase the susceptibility to gastric cancer.
In order to simulate the intervention effect of Helicobacter pylori-mediated abnormal crotonylation of EB1 on the renewal quality of gastric epithelial cells, the collaborative team established TIP60 mutant gene knock-in mice, and successfully obtained visualized three-dimensional gastric organoids to carry out near-physiological status Real-time cell renewal quality control dynamics research
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