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December 30, 2021/MedClub PR News/--In 2019, Dr.
Dennis Jeppesen of Coffey Laboratory Research Institute used advanced technology to isolate extracellular vesicles, also called exosomes
.
In the same year, Dr.
Qin Zhang, another colleague of Coffey and a medical research assistant professor, used high-speed ultracentrifugation to separate a kind of uncoated nanoparticles called exocrine particles
.
Researchers at Vanderbilt University Medical Center in the United States separated the liquid left after the exosomal particles for a faster and longer time separation, and then a "super nanoparticle" appeared, which the researchers named Supermeres
.
Supermeres are morphologically different from exosomes, but Supermeres contain the same or even more substances that exist in exosomes, and are rich in potential biomarkers and therapeutic targets for many human diseases.
Diseases, Alzheimer's disease and other diseases related enzymes, proteins and RNA
.
Further, Supermeres functional substance is intercellular communication, the body having a greater absorption capacity, can be effectively absorbed multiple organs, including the liver, lung, colon and the like
.
▲Extracellular vesicles and particles Recently, researchers from the Vanderbilt University Medical Center in the United States published this result in the journal Nature Cell Biology.
By understanding the role of extracellular vesicles and nanoparticles in cell information transmission Role, a more in-depth study of the Supermeres discovered this time may be able to explore new biomarkers and targets
.
Professor Robert Coffey of Vanderbilt University Medical Center is a well-known intestinal tumor expert and is actively exploring whether the detection of Supermeres in the blood can achieve earlier diagnosis and treatment of diseases
.
At the same time, he also said that although it has been established that the biomarkers and therapeutic targets of cancer and other diseases can be reflected in Supermeres, it is necessary to figure out how these substances are released
.
Supermeres carry RNA released by cells and widely stored in the blood.
Secondly, Supermeres from cancer can "transfer" to drug-resistant tumor cells.
This may be through Supermeres to transfer RNA between each other
.
Researchers found that Supermeres is an important carrier of TGFBI, and TGFBI protein is a secreted protein induced by transforming growth factor β
.
The researchers pointed out that in the study of colorectal cancer patients, compared with normal colon tissue, the TGFBI immunoreactivity in colorectal cancer patients was greatly increased
.
Compared with control individuals, higher levels of TGFBI were found in all the extracellular components isolated from the plasma of the three colorectal cancer patients.
It can be seen that TGFBI may be a potential biomarker in colorectal cancer
.
▲ Supermere shows a unique proteome with high levels of TGFBI.
Supermeres also carry angiotensin converting enzyme 2 (ACE2) as a bait, which is a cell surface receptor that plays a role in cardiovascular disease and is also a target of the COVID-19 virus ACE2 combines with the virus to prevent infection
.
In addition, another potential biomarker of Supermeres is β-amyloid precursor protein (APP).
In Alzheimer's disease, APP is related to the disease
.
Supermeres can cross the blood-brain barrier, and APP is shed from the membrane proteins of other Alzheimer's disease-related diseases, and is highly enriched in Supermeres
.
It can be seen that through the analysis of Supermeres, the early diagnosis of Alzheimer's disease can be improved, and targeted treatment measures may even be taken
.
▲ Supermeres are rich in APP proteins that are shedding.
In short, Supermeres are rich in many shedding and clinically relevant membrane proteins, including APP, MET, GPC1, etc.
, which can be detected by optimized flow cytometry
.
These findings are of great significance for cancer, cardiovascular disease, Alzheimer's disease and even COVID-19
.
The application of exosomes, whether exosomes or exocrine particles, are widely present in various liquids, and carry a variety of proteins, mRNA and other substances, which are of great significance to the diagnosis and treatment of diseases
.
In the current treatment of diseases, exosomes have never been discovered, and then gradually attracted attention and become popular.
Exosomes are known as the next frontier field of cell therapy and have great application prospects, mainly including disease diagnosis and treatment.
On the one hand, it can be used as a drug delivery carrier, the immune activation and immunosuppressive function of exosomes against cancer, and as a diagnostic and prognostic marker of cancer
.
With the continuous in-depth study of exosomes, it can be found that exosomes have therapeutic potential in many diseases
.
Exosomes and tumor therapy Exosomes play a dual role in the development of tumors
.
On the one hand, it has the ability to inhibit the growth of tumor cells; on the other hand, exosomes can promote the occurrence and development of tumors, and play an important role in the process of tumor invasion and metastasis
.
Exosomes can also transport some substances to other tissues and organs through blood and body fluids, thereby achieving tumor metastasis
.
Therefore, the study of tumor exosomes will help to reveal the molecular mechanism of tumor formation and metastasis, and provide new ideas for the treatment of tumors
.
In December 2021, Codiak Bioscience, which focuses on the development of new exosomes therapies, announced that the US FDA has approved the IND application for the company’s third engineered exosome candidate drug exoASO-STAT6, initially planned for use in primary liver cancer.
.
Recommended reading: Exosomes and oligonucleotides join forces to fight cancer! This innovative therapy is advancing to the clinic.
Yimai Meng broke the news that exosomes and cardiovascular diseases are the first to use exosomes as potential therapeutic interventions for cardiovascular diseases.
It was published in 2010
.
At the beginning of the 21st century, some research groups showed that transplanting different types of cells, mainly including mesenchymal stem cells and hematopoietic progenitor cells or stem cells, can be found through experimental studies to improve heart repair after myocardial infarction (MI)
.
The positive effects of these stem cells or progenitor cells have been proved to be mediated by exosomes
.
According to the source and content of exosomes, various heart protective effects can be issued, such as improving the survival of cardiomyocytes and endothelial cells by regulating autophagy, activating pro-survival signaling pathways and reducing oxidative stress levels, affecting immune cell polarization and Cytokine secretion and increase the activation of CD4+ T cells to regulate the inflammatory response
.
Exosomes and arthritis-related diseases In the past few decades, with the in-depth study of exosomes, in addition to many studies that have found that exosomes secreted by cells under pathological conditions have an important role in osteoarthritis diseases, it has also been discovered that As a good biological signal transmission factor, the exosomes have a strong potential for repair and regeneration in cartilage
.
In addition to this, exosomes have also shown strong capabilities in the fields of immune system diseases, traumatic brain injury, skin repair, etc.
Therefore, exosomes are expected to become an emerging repair tool for "cell-free" treatment in regenerative medicine, making regeneration a Possible
.
How to promote the transformation of exosome technology has become the focus of industry attention
.
Under the guidance of the Exosomes Specialized Committee of the Tumor Markers Committee of the Chinese Anti-Disease Association, Yimike organized the 2021 Exosomes Technology Transformation Forum in conjunction with many exosomes research institutions and enterprises in the industry
.
This forum will be broadcast live simultaneously on the Yimicke live platform Yimai classroom and Yimaike Tencent video account.
We sincerely invite you to participate in this forum to jointly promote the transformation of exosomes! Reference materials: 1.
https:// https:// Disclaimer: This article involves content only It is used to explore the forefront of biomedicine and does not constitute any medical guidance.
If necessary, please go to a regular hospital for treatment
.
Dennis Jeppesen of Coffey Laboratory Research Institute used advanced technology to isolate extracellular vesicles, also called exosomes
.
In the same year, Dr.
Qin Zhang, another colleague of Coffey and a medical research assistant professor, used high-speed ultracentrifugation to separate a kind of uncoated nanoparticles called exocrine particles
.
Researchers at Vanderbilt University Medical Center in the United States separated the liquid left after the exosomal particles for a faster and longer time separation, and then a "super nanoparticle" appeared, which the researchers named Supermeres
.
Supermeres are morphologically different from exosomes, but Supermeres contain the same or even more substances that exist in exosomes, and are rich in potential biomarkers and therapeutic targets for many human diseases.
Diseases, Alzheimer's disease and other diseases related enzymes, proteins and RNA
.
Further, Supermeres functional substance is intercellular communication, the body having a greater absorption capacity, can be effectively absorbed multiple organs, including the liver, lung, colon and the like
.
▲Extracellular vesicles and particles Recently, researchers from the Vanderbilt University Medical Center in the United States published this result in the journal Nature Cell Biology.
By understanding the role of extracellular vesicles and nanoparticles in cell information transmission Role, a more in-depth study of the Supermeres discovered this time may be able to explore new biomarkers and targets
.
Professor Robert Coffey of Vanderbilt University Medical Center is a well-known intestinal tumor expert and is actively exploring whether the detection of Supermeres in the blood can achieve earlier diagnosis and treatment of diseases
.
At the same time, he also said that although it has been established that the biomarkers and therapeutic targets of cancer and other diseases can be reflected in Supermeres, it is necessary to figure out how these substances are released
.
Supermeres carry RNA released by cells and widely stored in the blood.
Secondly, Supermeres from cancer can "transfer" to drug-resistant tumor cells.
This may be through Supermeres to transfer RNA between each other
.
Researchers found that Supermeres is an important carrier of TGFBI, and TGFBI protein is a secreted protein induced by transforming growth factor β
.
The researchers pointed out that in the study of colorectal cancer patients, compared with normal colon tissue, the TGFBI immunoreactivity in colorectal cancer patients was greatly increased
.
Compared with control individuals, higher levels of TGFBI were found in all the extracellular components isolated from the plasma of the three colorectal cancer patients.
It can be seen that TGFBI may be a potential biomarker in colorectal cancer
.
▲ Supermere shows a unique proteome with high levels of TGFBI.
Supermeres also carry angiotensin converting enzyme 2 (ACE2) as a bait, which is a cell surface receptor that plays a role in cardiovascular disease and is also a target of the COVID-19 virus ACE2 combines with the virus to prevent infection
.
In addition, another potential biomarker of Supermeres is β-amyloid precursor protein (APP).
In Alzheimer's disease, APP is related to the disease
.
Supermeres can cross the blood-brain barrier, and APP is shed from the membrane proteins of other Alzheimer's disease-related diseases, and is highly enriched in Supermeres
.
It can be seen that through the analysis of Supermeres, the early diagnosis of Alzheimer's disease can be improved, and targeted treatment measures may even be taken
.
▲ Supermeres are rich in APP proteins that are shedding.
In short, Supermeres are rich in many shedding and clinically relevant membrane proteins, including APP, MET, GPC1, etc.
, which can be detected by optimized flow cytometry
.
These findings are of great significance for cancer, cardiovascular disease, Alzheimer's disease and even COVID-19
.
The application of exosomes, whether exosomes or exocrine particles, are widely present in various liquids, and carry a variety of proteins, mRNA and other substances, which are of great significance to the diagnosis and treatment of diseases
.
In the current treatment of diseases, exosomes have never been discovered, and then gradually attracted attention and become popular.
Exosomes are known as the next frontier field of cell therapy and have great application prospects, mainly including disease diagnosis and treatment.
On the one hand, it can be used as a drug delivery carrier, the immune activation and immunosuppressive function of exosomes against cancer, and as a diagnostic and prognostic marker of cancer
.
With the continuous in-depth study of exosomes, it can be found that exosomes have therapeutic potential in many diseases
.
Exosomes and tumor therapy Exosomes play a dual role in the development of tumors
.
On the one hand, it has the ability to inhibit the growth of tumor cells; on the other hand, exosomes can promote the occurrence and development of tumors, and play an important role in the process of tumor invasion and metastasis
.
Exosomes can also transport some substances to other tissues and organs through blood and body fluids, thereby achieving tumor metastasis
.
Therefore, the study of tumor exosomes will help to reveal the molecular mechanism of tumor formation and metastasis, and provide new ideas for the treatment of tumors
.
In December 2021, Codiak Bioscience, which focuses on the development of new exosomes therapies, announced that the US FDA has approved the IND application for the company’s third engineered exosome candidate drug exoASO-STAT6, initially planned for use in primary liver cancer.
.
Recommended reading: Exosomes and oligonucleotides join forces to fight cancer! This innovative therapy is advancing to the clinic.
Yimai Meng broke the news that exosomes and cardiovascular diseases are the first to use exosomes as potential therapeutic interventions for cardiovascular diseases.
It was published in 2010
.
At the beginning of the 21st century, some research groups showed that transplanting different types of cells, mainly including mesenchymal stem cells and hematopoietic progenitor cells or stem cells, can be found through experimental studies to improve heart repair after myocardial infarction (MI)
.
The positive effects of these stem cells or progenitor cells have been proved to be mediated by exosomes
.
According to the source and content of exosomes, various heart protective effects can be issued, such as improving the survival of cardiomyocytes and endothelial cells by regulating autophagy, activating pro-survival signaling pathways and reducing oxidative stress levels, affecting immune cell polarization and Cytokine secretion and increase the activation of CD4+ T cells to regulate the inflammatory response
.
Exosomes and arthritis-related diseases In the past few decades, with the in-depth study of exosomes, in addition to many studies that have found that exosomes secreted by cells under pathological conditions have an important role in osteoarthritis diseases, it has also been discovered that As a good biological signal transmission factor, the exosomes have a strong potential for repair and regeneration in cartilage
.
In addition to this, exosomes have also shown strong capabilities in the fields of immune system diseases, traumatic brain injury, skin repair, etc.
Therefore, exosomes are expected to become an emerging repair tool for "cell-free" treatment in regenerative medicine, making regeneration a Possible
.
How to promote the transformation of exosome technology has become the focus of industry attention
.
Under the guidance of the Exosomes Specialized Committee of the Tumor Markers Committee of the Chinese Anti-Disease Association, Yimike organized the 2021 Exosomes Technology Transformation Forum in conjunction with many exosomes research institutions and enterprises in the industry
.
This forum will be broadcast live simultaneously on the Yimicke live platform Yimai classroom and Yimaike Tencent video account.
We sincerely invite you to participate in this forum to jointly promote the transformation of exosomes! Reference materials: 1.
https:// https:// Disclaimer: This article involves content only It is used to explore the forefront of biomedicine and does not constitute any medical guidance.
If necessary, please go to a regular hospital for treatment
.
