Scientists have uncovered specific genetic factors behind different tumor subtypes and their prognosis

Recently, scientists from the University of Cologne and other institutions in Germany have uncovered special genetic factors behind different tumor subtypes and their prognosis through research Relevant research results may help clinicians accurately predict the clinical progress of patients' diseases, and take appropriate treatment for patients Relevant research is published in the international journal Science Dr Johannes Schulte, researcher, said that the results of this study may provide a new method to classify different neuroblastoma phenotypes and help us to successfully analyze the genetic code of neuroblastoma cells In this paper, the researchers identified mutations in Ras and p53 cancer signal transduction pathways that are directly related to poor prognosis In addition, the researchers also found that some patients with mutations will also have tumor self regression Only by combining the genetic data of these cancer signal transduction pathways with the information responsible for maintaining the mechanism of telomere length, can the researchers have a deep understanding of the mechanism of generating different neuroblastoma subtypes, and it is also expected to help develop precise chemotherapy to improve the treatment of patients Law Telomere plays the role of molecular clock in human cells In most cells, telomere will shorten with the number of cell divisions Once it reaches the critical length, the cell will receive the signal to stop dividing, which leads to cell growth stop or cell death However, stem cells or most cancer cells have telomere maintenance mechanism, which can ensure telomere maintenance The length is kept above the critical length, so as to effectively keep the cells immortal The researchers found that if these telomere maintenance mechanisms were present, neuroblastoma would unfold (http://www.chemdrug.com/exhibit/) There is a trend of malignant growth, and the patients with additional mutations in the above cancer signal pathway often have poor prognosis Considering that the current treatment can not effectively treat most cancer patients, the researchers hope to develop a new individualized treatment for patients The results of this study indicate that the activation of telomere maintenance mechanism may play a key role in the occurrence of malignant tumors The results of this study may provide new ideas for later scientists to develop new individualized therapy In the future, the new therapy developed by researchers is expected to block the signal pathway of cancer and telomere maintenance mechanism.