Scientists have revealed the immune mechanisms of malaria parasites against liver tumors

, Chen Xiaoping of the Guangzhou Institute of Biomedicine and Health of the Chinese Academy of Sciences revealed for the first time the immune mechanism of malaria parasite as a tumor antigen expression vector and its anti-liver tumor (HCC), which provides strong preclinical data support for the use of malaria parasite in tumor immunotherapy. The results of the research have been published online
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the use of antigens to activate the body's immunity, tumor immunotherapy is one of the important ways of tumor vaccine. However, most antigen-induced specific immunity is often strong enough but not persistent enough. Chen Xiaoping's team stimulated the body to produce specific CD8-T lymphocytes for GPC3 to kill tumor cells by building mice with plasmodium glycogen immunology tumors expressing GPC3 proteins.
results showed that the malaria parasite, which expresses GPC3 protein, was significantly inhibited after immune mice, and their survival rate was significantly improved. At the same time, the persistent infection of the malaria parasite provides good conditions for the long-term expression and release of tumor antigens. The study further discusses the feasibility of activating tumor-specific CD8-T lymphocytes to kill tumors with human malaria parasite, and with the deepening of the research on red endothosis and liver endotysis strains, the clinical prospect of genetically modified malaria parasites for tumor immunotherapy is very promising. (Source: China Science Journal Zhu Hanbin Huang Boquan)