Scientists have revealed that intestinal nociceptors mediate host defense

Recently, researchers from Harvard Medical School and other scientific research institutions in the United States published a report on the cell entitled "guts innovative nociceptor neurons regulate Peyer's patch microfold cells and SFB levels to mediate Salmonella host Defense "reveals that the gut nociceptor neurons mediate host defense against Salmonella by regulating the level of collecting lymph node pleated cells and SFB The gut nociceptor neurons respond to harmful stimuli by initiating protective responses such as pain and inflammation However, their role in gut infection is unclear In this study, researchers found that nociceptor neurons mediate host defense against serotype Salmonella typhimurium (STM) Dorsal root ganglion nociceptors can prevent STM from colonization, invasion and transmission Nociceptors regulate the density of pleated cells in follicular associated epithelia (FAE) of ileal collecting lymph nodes, thus limiting the invasion of STM In the downstream of pleated cells, the nociceptors maintain the level of segmental filamentous bacteria (SFB), which is a kind of intestinal microorganism located on FAE of ileum villi and collecting lymph nodes, and can mediate the defense of STM infection TRPV1 + (transient receptor potential vanillic acid 1) nociceptors respond to STM by releasing calcitonin gene-related peptide (CGRP), a neuropeptide that regulates the level of pleated cells and SFB to prevent Salmonella infection This study revealed the main role of nociceptive neurons in the perception and defense of intestinal pathogens.