Scientists have revealed new mechanisms between ADHD and sleep disorders

Recently, Feng Jianfeng and Luo Qiang, dean of Fudan University's Institute of Brain Intelligence Science and Technology, in collaboration with the University of Cambridge in the United Kingdom and the University of Ottawa in Canada, made important progress in the study of ADHD and sleep disorder co-disease, found brain imaging evidence of early ADHD symptoms causing late-stage sleep problems, and prompted the relevant molecular biology process. The findings were published online in the journal Biopsychotics.
ADHD is a high proportion in children, often accompanied by sleep disorders that negatively affect the development of the child's nervous system and family quality of life, and can even affect schooling and increase the risk of accidents.
To clarify the causal relationship between ADHD and sleep problems, the study used the QLSCD birth queue in Quebec, Canada, and the ABCD queue for brain development in U.S. school-age children, using causal inference statistical models to find that the more severe ADHD symptoms in the early stages led to more sleep problems later in life.
To understand the neurobiological mechanisms of causation, the team conducted a study of brain structure imaging (n-3515) and identified several key brain regions associated with ADHD symptoms and sleep problems, mainly in attention networks and wakefulness systems. In these brain regions, less gray matter is associated with more severe ADHD symptoms, which can lead to more sleep problems later in life.
team, through gene transcriptomic histological analysis, found that some special genes mainly involved in molecular biological processes such as circadian rhythm and neurosignal conduction were expressed more in the above-mentioned brain regions, and found brain imaging evidence that early ADHD symptoms caused late-stage sleep problems.
ADHD patients have sleep problems that often affect the quality of life of patients and their families and have a negative impact on children's academic performance. Professor Barbara Sakhakin, Fellow of the Royal Society of Medical Sciences, Professor of Science, Fudan University, Honorary Doctorate, University of Cambridge, Department of Mental Medicine.
The study looked at the common phenomenon of ADHD and sleep disorders, using longitudinal brain image follow-up queues and causal analysis statistical models, and found that AHDH symptoms significantly increased sleep problems in children, revealing the mechanism of ADHD and sleep disorder co-disease. "More importantly, we have found genes and brain structures associated with this," said Dr. Luo Qiang, one of the paper's lead researchers. Feng
, a professor at the University of California, said the study's findings could help develop and design new treatments for early-stage ADHD to reduce ADHD symptoms and sleep problems in patients.
the study was supported by funding from the National Natural Science Foundation of China, the Shanghai Basic Transformational Application of Brain and Brain Intelligence, and the Shanghai Science and Technology Commission's Science and Technology Innovation Program. (Source: Huang Xin, China Science Journal)
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