Scientists have made new progress in the field of cancer metastasis and spread!

Delved into cellular signals that control cancer growth and migration or can help find effective anti-cancer drugs In a recent study published in the international journal Journal of Biological Chemistry, scientists from McGill University and others have found or can help understand key birth processes for the pathogenesis of colorectal cancer. In the
paper, the researchers analyzed the behavior of key enzymes involved in the spread of cancer cells, noting that there may be a more refined interaction between an enzyme called PRL3 and another protein that moves magnesium ions inside and outside the cell, which is essential for the growth of colorectal cancer.
researcher Dr Kalle Gehring said the enzymes first appeared in liver cells that are activated to open up cell growth, so they may be able to act as growth signals; the PRL3 protein is thought to act as a special enzyme that controls cancer cells, while researchers have found that a mutation that promotes the absence of PRL3 activity may remain In this study, researchers found that the second activity of prL3 enzyme, the control of magnesium ion transport proteins, which guide the spread of cancer cells in other parts of the body, does not appear to catalytic activity, but is closely integrated with magnesium ion transport proteins and has the same carcinogenic properties as wild proteins.
Image Source: Chinese Academy of Sciences 6 JAMA Network Open: Chinese scientists have developed a new deep learning technique that promises to successfully predict hidden peritometrial metastasis in patients with stomach cancer! doi:10.1001/jamanetworkopen.2020.32269 Stomach cancer is a common gastrointestinal malignancies that often occur in most patients with advanced stomach cancer, which is considered an invasive cancer and often has poor prognosis.
patients with peritina metastasis for stomach cancer are generally not suitable for root-and-drug surgery;
a recent study published in the international journal JAMA Network Open entitled "Noninvasive Prediction of Occult Peritoneal Metastasis in Gas Cancertric Using Deep Learning" by scientists from the Shenzhen Institute of Advanced Technology of the Chinese Academy of Sciences and others Research has developed a deep learning technique to help predict hidden peritometrial metastasis in patients with stomach cancer, and in this article, researchers offer a new and non-invasive way to diagnose gastric cancer patients, with the results promising to help develop individualized surgical treatments for gastric cancer patients.
: Nat Med: Breakthrough! Scientists reveal why cancer patients with liver metastasis have poor prognostics! Doi:10.1038/s41591-020-1131-x In a recent study published in the international journal Nature Medicine, scientists from the University of Michigan and others used research to explain why patients with cancer spread to the liver tend to have poor prognosis.
researchers point out that when cancer patients' cancer cells spread to the liver, their condition tends to be worse than cancer cells spread to other parts of the body, and that transformative immunotherapy tends to treat these patients less effectively. In the
study, researchers uncovered the causes and a possible solution, finding that tumors in the liver may "siphon" critical immune cells and make immunotherapy ineffective, but combining immunotherapy with radiotherapy in the liver in mice could restore the function of these immune cells and produce better therapeutic results.
researcher Michael Green says cancer liver metastasis patients may have little benefit from immunotherapy, but immunotherapy has now changed the treatment strategies for multiple cancers; this study suggests that we may be able to use radiotherapy to reverse this tolerance, which may have a real impact on the prognostication of treatment.
: Nat Commun: Special regulatory RNAs may promote metastasis of breast cancer! doi:10.1038/s41467-020-20207-y A recent study published in the international journal Nature Communications entitled "MaTAR25 lncRNA regulates the Tensin1 gene to impact breast cancer progression" In the report, scientists from cold spring harbor laboratories and others found that a gene-regulated RNA fragment could promote the spread of multiple breast cancers; in animal models, researchers may be able to inhibit the growth of metastatic tumors using a specific molecule that targets RNA and induces its destruction, and the same strategy may be used to help develop new breast cancer therapies.
as early as 2016, researcher Spector and colleagues found that breast cancer cells may have a wide range of RNA molecules, all long-chain non-coding RNAs (lncRNAs), that do not encode proteins, but In this study, researchers revealed how one of these lncRNA molecules, called Mammary Tumor-Associated RNA 25, a breast tumor-related RNA 25, affects the behavior of breast cancer cells in mice.
9 Nature: Heavy! Scientists have successfully mapped the metastasis of human cancer cell lines! Doi:10.1038/s41586-020-2969-2 Recently, in a study published in the international journal Nature entitled "A metastasis map of human cancer cell lines", scientists from the Broad Institute and other institutions in the United States have successfully mapped the metastasis of human cancer cell lines, the results of which may help clarify the metastasis of cancer and the development of new therapies to prevent cancer metastasis and cancer treatment.
<!--ewebeditor:page title"--most deaths from > cancer can be explained by cancer metastasis, but large-scale cancer metastasis studies have been impractical due to the complex nature of in vivo models. In the
study, researchers introduced an in vivo bar code strategy that can determine the metastasis potential of human cancer cell lines in mouse foreign transplants on a large scale, confirming the stability, scalability and repeatability of the new method and applying it to 500 cell lines from 21 different types of solid tumors.
(10) Cell Rep: Before scientists can successfully reveal the origin of cancer cell metastasis and the new molecular mechanism doi:10.1016/j.celrep.2020.108372 Before they can design effective treatments, researchers must understand the specifics of the cells or cell types that induce cancer metastasis in the heterogeneity of large tumors