Scientists find that green cohosh extract, a traditional Chinese medicine, can inhibit breast cancer

Scientists from the Chinese Academy of Sciences found that the extract of green cohosh has the effect of inhibiting triple negative breast cancer The research results have been published in the international journal treatment and diagnosis recently Triple negative breast cancer is one of the most malignant types of breast cancer At present, the treatment of triple negative breast cancer is still at the traditional level of chemotherapy Patients have a high recurrence rate after treatment, and cancer cells are easy to metastasize It is urgent to find new treatment targets and effective drugs to improve the survival rate of triple negative breast cancer patients Ranunculaceae is a famous traditional Chinese medicine in China Its medicinal value has been recorded as early as in Shennong materia medica Its underground roots are used as medicine, with the effect of clearing away heat and detoxification It is used by the people to treat sore throat, toothache and gynecological diseases In recent years, the research shows that the three kinds of compounds extracted from Cimicifuga have the biological activities of anti-tumor, anti malaria, reducing blood lipid and so on Green cohosh is a kind of cohosh Scientists from Kunming Institute of zoology, Chinese Academy of Sciences and Kunming Institute of Botany, Chinese Academy of Sciences found the anti-cancer mechanism of green cohosh extract on three negative breast cancer through joint research According to Kong Yanjie, the first author of the paper and doctoral student in the group of oncobiology of Kunming Institute of zoology, Chinese Academy of Sciences, researchers isolated and purified a large number of three kinds of monomer compounds from the dried tubers of green cohosh Through screening, it was found that the active compound khf16 could significantly inhibit the survival of three negative breast cancer cell lines in vitro Further study found that khf16 can induce apoptosis and cycle arrest of cancer cells and reduce the expression level of drug-resistant protein by inhibiting the proliferation and survival related signal pathway of triple negative breast cancer cells, so as to achieve the effect of inhibiting the proliferation of cancer cells "In our study, we also found that khf16 has the same inhibitory effect on gastric cancer, liver cancer and osteosarcoma It can be seen that the isolation and screening of monomer components inducing apoptosis of cancer cells from traditional Chinese medicinal plants will lay an important foundation for the development of new anti-tumor drugs." Kong Yanjie said.