Scientists have found that memory reproduction is related to brain clock

Recently, researchers from Tokyo University and other universities published an article entitled "hippocampal clock regulations memory retrieval via dopamine and PKA induced GluA1 phosphorylation" on nature communications It was found that memory reproduction is related to brain biological clock, and related specific genes were identified in mice People's cognitive ability is different in a day From late afternoon to late evening, memory reproduction function will be significantly reduced At present, the function of local brain clock in memory performance is not clear The researchers found that the hippocampus clock, controlled by the circadian rhythm dependent transcription factor BMAL1, regulates the time of day for memory retrieval The negative expression of BMAL1 (dnbmal1) in the forebrain or hippocampus of mice can interfere with the memory reproduction of hippocampus at the time of zeitgeber time (ZT) 8-12, which is related to the down-regulation of dopamine cAMP signal in the hippocampus of dnbmal1 mice Specifically, d1-r and d5-r expression of dopamine receptors and glua1-s845 phosphorylation regulated by PKA (protein kinase A) decreased At the same time, in dnbmal1 mice, cAMP signal or D1 / 5RS pharmacological activation saved the recovery of damaged memory More importantly, GluA1 s845a knockin mice showed similar memory recall deficits to dnbmal1 mice In this study, BMAL1 was associated with the activation of dopamine receptor and the modification of other small signal molecules in the brain, and the mechanism of modulation of hippocampal clock by GluA1 phosphorylation mediated by D1 / 5r-camp-pka was proved