Scientists have found that aging proteins help develop anti-aging drugs

Japanese researchers published an article in the electronic edition of the American science journal Cell, announcing the discovery of proteins that can lead to aging Kyodo News Agency reported that a research team composed of Osaka University, Hokkaido University and Chiba University found that the protein was more in the blood and organs of old mice than that of young mice; if the protein could not be generated, arteriosclerosis and other phenomena would be reduced The human body also contains this protein If anti-aging drugs can be developed to inhibit its generation, it is possible to prevent and treat diseases that are prone to develop with age, such as diabetes, dementia, cancer and heart failure However, due to the immune function of the protein to repel the invading bacteria and viruses, the development of new drugs still faces many problems The team found that the blood of two-year-old mice belonging to the elderly contained more than five times the "C1q" protein of two-month-old mice The team also found that C1q also increased in the heart, lungs and other organs of old mice Due to the effect of C1q, the proteins named "LRP5" and "LRP6" on the cell surface are cut off, leading to aging The team believes that this causes abnormal tissue regeneration Through gene recombination, the team failed to generate C1q in mice, which confirmed that muscle regeneration became active and symptoms of heart failure, arteriosclerosis and diabetes were also improved Although C1q plays an important role in the body's immune activities, too much of it can cause aging, according to the team's analysis It is not clear why the protein increases with age Although there are still many difficulties in clinical application, the results have made human beings step forward to the dream of anti-aging, said the research team member and Osaka University Professor Shi Yicheng (source: Lianhe Zaobao)