Scientists have discovered a mechanism for the proliferation of non-coded RNA in liver cancer cells

scientists in China have discovered two non-coding RNA mechanisms that regulate the molecular action of liver cancer cell proliferation through quantitative proteomics. This is the reporter 13 from the Chinese Academy of Sciences Institute of Aquatic Biology received the news.
, non-coding RNA refers to RNA molecules that cannot encode proteins. Non-coding RNA with regulatory action mainly includes microRNAs, long-chain non-coding RNAs, and cyclic RNA.
Ge Feng Research Group of the Institute of Aquatic Biology of the Chinese Academy of Sciences has been working for many years to reveal the molecular regulatory networks of non-coded RNA and their mechanisms of action using quantitative proteomics techniques. CDR1as is a ring RNA molecule associated with the occurrence of a variety of cancers and neurological diseases. Ge Feng's team constructed a protein regulatory network of CDR1as in liver cancer cells. The study found that CDR1as can regulate the expression of the skin growth factor receptor by targeting miR-7 molecules, which in turn affects the proliferation of liver cancer cells, revealing the new molecular mechanism of CDR1as in liver cancer cells.
HOTAIR is a long-chain non-coding RNA closely related to tumor occurrence. Ge Feng's research team constructed THETAIR's molecular regulatory network in liver cancer cells. The study found that HOTAIR's role in promoting the proliferation of liver cancer cells can be achieved by regulating the expression of opioid growth factor receptors, which may be prevalent in various types of cancer cells.
, these two results have been published in the international authoritative journals Proteomics Research
and International Journal. The two findings are important for revealing the molecular mechanisms of cancer and finding more effective treatments, said the head of the Institute of Aquatic Biology of the Chinese Academy of Sciences. (Source: Xinhua News Agency, Tan Yuanbin