-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
Image: In a laboratory, an image of human cells' DNA being destroyed by a laser beam
The human body is composed of trillions of cells, and each cell suffers more than 10,000 DNA damages every day
Martinez explained that once DNA damage occurs, such as a DNA double-strand break, the cell activates a mechanism called DNA damage response, just like "calling emergency services
The purpose of chemotherapy is to kill tumor cells by inducing DNA damage, leading to the collapse and death of cancer cells
Researchers have developed a new method that can analyze this process with unprecedented detail and precision with the help of the machine learning analysis method designed by the CNIO confocal unit
Researchers used high-throughput microscopy technology to obtain thousands of cell photos after inducing genetic damage
But the authors decided to go a step further and visually inspect these 300 proteins after gene damage
"We found that many proteins will adhere to damaged DNA, while others will be the opposite: they will stay away from damaged DNA
One of the proteins discovered is PHF20
These technologies provide new opportunities for studying DNA repair and manipulation of DNA
This work was funded by the Spanish Ministry of Science and Innovation, Carlos III Institute of Health, National Institutes of Health, Marie Curie Joint Fund FP7, Massachusetts General Hospital, European Research Council, and Canadian Natural Science and Engineering Research Council.
Article title
Assessing kinetics and recruitment of DNA repair factors using high content screens
