Scientists found that serum amyloid A promotes the development of inflammatory diseases

Recently, researchers from the Medical College of New York University and other research institutions published an article entitled "serum amyloid A proteins induce pathogenic Th17 cells and promote inflammatory disease" on cell It was found that serum amyloid A promotes the occurrence of inflammatory diseases by inducing pathogenic Th17 cells Lymphocytes produce interleukin (IL) - 17, which protects the barrier tissue from pathogens They are also important effectors of inflammation and autoimmune diseases T helper 17 cell (Th17), defined by the production of IL-17A and IL-17F, plays a steady-state role in the intestinal tract after directional differentiation from the original CD4 + T cells In nonpathogenic environment, the production of cytokines by Th17 cells is regulated by serum amyloid a protein (SAA) secreted by adjacent intestinal epithelial cells However, the activity of Th17 cells changes with the environment In this study, researchers found that SAA can regulate the differentiation process of pathogenic pro-inflammatory Th17 cells, and interact directly with signal transducer and activator of transcription (STAT3) activating cytokines on T cells Using mice models of loss of function and function gain, researchers found that SAA1, saa2 and SAA3 have unique systemic and local functions in promoting Th17 mediated inflammatory diseases This study suggests that T cell signaling pathway regulated by SAA may be a potential target of anti-inflammatory therapy.