Scientists discovered the transcription basis of dendritic cell heterogeneity in mice and human

Dendritic cell, also known as DC cell, is a kind of cell which not only has branch or dendritic morphology and phagocytic function, but also can present antigen It can be divided into medullary and lymphatic systems Mature DC cells are called dendritic cells because of their dendritic or pseudopodoid processes Dendritic cells, like sentinels, are immature in the peripheral tissues, but they have strong ability of antigen endocytosis and processing After it ingests antigens or is stimulated by some factors, it can differentiate and mature, migrate at the same time, enter the secondary lymphoid organs through the lymphatic vessels and blood circulation from the peripheral tissues, and then stimulate the T cell response It is the central link to start, regulate and maintain immune response A large number of dendritic cells loaded with tumor antigen were activated and cultured in vitro When the number of dendritic cells reached a certain number, they were infused back to patients, which could induce strong anti-tumor immune response Recently, researchers from the memorial Sloan Caitlin cancer center and other research institutions in the United States published an article entitled "transcribed basis of mouse and human dendritic cell heterogeneity" on cell, which found the transcription basis of the heterogeneity of mouse and human dendritic cells Dendritic cells (DCS) play an important role in the coordination of acquired immunity They have the unique ability to start T cell response and differentiate it into effect family Based on the phenotypic markers of DCS and their ability to activate CD8 and CD4 T cells, classic DCs are divided into cdc1 and cdc2 Previous studies have elucidated the transcriptional regulation mechanism of cdc1, but little is known about the development and function of CDC2 By combining transcription and chromatin analysis with gene expression reports, researchers have identified two major cdc2 lineages, which are defined by different developmental pathways and transcription factors, including T-box transcription factor (T-bet) and retinoic acid related orphan receptor (ROR γ T), which respectively define the innate and acquired lymphocyte subsets These newly discovered cdc2 lineages are characterized by unique metabolism and function This study will reveal the conserved DC heterogeneity in human cancer and the existence of a newly defined cdc2 subtype