Scientists discover new functions of oncogene MYC

Recently, scientists from Jackson's lab found new features in myMYC, a powerful cancer gene that is estimated to affect MYC, a powerful cancer gene, in a study published in the international journal Journal of Lab Medicine, in a recent study published in the international journal Journal of Lab MedicineMYC can drive a series of cancers by enhancing the growth and proliferation of tumor cells, mainly because MYC can be used as a transcription factor to control the production of multiple mRNAs in cells, but there is evidence that MYC may be able to control the process of translating mRNA into proteins, usually done by ribosomesThe researchers analyzed different types of mRNAs translated by ribosomes in lymphoma cells with high or low levels of MYC, and found that high levels of MYC stimulated the translation of specific types of mRNAs, many of which were able to encode the components of respiratory complexes, thus promoting the energy generated by cell mitochondriaWhen MYC is missing, SRSF1 and RBM42 proteins can bind to these mRNAs and inhibit their translation by ribosomes, however, when MYC levels are high, SRSF1 and RBM42 cannot be combined with mRNA, which will be transformed into a free state called respiratory complex protein, so MYC can promote the production of myrhesis and accelerate the rapid growth and proliferation of lymphomasMYC can affect the amount of mRNA translated by ribosomes, resulting in long-chain or broken-chain proteins, for example, low-level MYC lymphoma cells produce shortened versions of CD19 protein, unlike the complete CD19 protein, which is no longer exposed to the surface of cancer cellsthis is important because scientists often use CAR-T immune cells to treat lymphoma, CAR-T immune cells can be genetically engineered to identify and kill cancer cells that express CD19, and surface deletion CD19 is often associated with cancer cells' tolerance to CAR-T cell therapy, but researchers do not know how lymphocytes lower the level of CD19 on the surface of cells, and they have found that CAR-T cells are no longer able to identify and kill missing CD19 lymphomasfinal researcher Han-Guido Wendel said that, however, the study found that MYC could affect the production of key metabolic enzymes and immune receptors in lymphoma cells by regulating the efficiency of mRNA translation and the stability of protein synthesis, and that the next step is to further study the molecular mechanisms that illustrate the molecular mechanisms of MYC's regulation of different aspects of protein production in cancer cellsoriginal origin:Kamini Singh, Jianan Lin, Yi Zhong, et al.c-MYC regulate mRNA tranlation efficiency and tart-ite in lymphoma, JEM (2019) doi:10.1084/jem.20181726