Scientists develop mini-lung tissue for SARS-CoV-2 study

, June 7, 2020 /
BiovalleyBIOON/ -- Recently, scientists from the University of Bochum Ruhr want to study the SARS-CoV-2 infection process and identify potential antiviral substances usingstem cells-derived organs;stem cellsdifferentiated human lung organs, which could help them test for a variety of active substances during high-flow screening, an analysis called SARS-Cov-2 infecting human lung organs, by researchers Suchas Thorsten MullerPicture Source: NIAID
Investigating the complex interrelatedof different cell types is similar to embryos, the organ-like organs are derived from induced pluripotentstem cells, and compared with the animal models previously used by the researchers and cell cultures based on human lung tissue, the organ-like organs have several advantages, namely, they come from human cells, can be mass produced, and have the samegeneticbackground, so there are no differences between them from different donorsthe organ can form a reliable 3-D model that helps researchers study the complex interactions between different cell types in lung tissue, and the researchers aim to optimize the model into a high-throughput method with a lower rate of mutation to study SARS-Cov-2 infections, and the researchers say the team is currently interested in studying virus replication, COVID-19, inflammatory mechanisms and the release of immune messengers in lung tissuethe virus emits green light under the microscope
the researchers analyzed the occurrence of infection rates when given to the likes of Remdesivir, Camostat and chloroquine, and future researchers will test a range of new substances, said Stephanie Pfander, a researcher who says, we will use a reported sub-SARS-Cov-2 virus to incorporate green fluorescent proteins into their genomesrecently researchers are working on how to produce the first SARS-Cov-2 molecular clone, a system that could help researchers manipulate the viral genome to ingest reported genes, using high-resolution microscopes, and will study the interactions and infection mechanisms between viruses and organ-like organs, a new method they hope will find for a suitable antiviral agent (BiovalleyBioon.com) original source: Researchers Research mini-club for SARS-CoV-research 2
A Bochum-based team intends to use the organs from the cells to the study the progression of SARS-CoV-2 infection and In order to study the details of the infection with the novel corona virus SARS-Cov-2 under the most of natural s, a research team at Ruhr-universit ss ss t Bochum (RUB) is growing human lungoids from stem cells This method also enables them to carry out tests with all active substances in a high-sgch a tha Project "Analysis of SARS-Cov-2 infected human lung lung organoids", organsars for short, is head by associate professor Dr Thorsten M?ller und Professor Stephanie Pf?nder and will be be fund ed by the federal nod