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For the first time, researchers at the University of North Carolina at Chapel Hill have measured biomarker concentrations of azoesters (AZ), a commonly used fungicide, in the urine of pregnant women and children aged 40-84 mont.
The researchers' experimental data, published in the journal Environmental Health Perspectives, also found that the concentration of AstraZeneca in the brains of mice in utero correlated with the environme.
"The most concerning aspect of our study is that this fungicide is now widely used in some brands of mold-resistant wallboard," said senior author .
Zylka, who holds the distinguished professor of cell biology and physiology at the UNC School of Medicine, began studying the effects of the germicide on brain cells a few years ago when he and his colleagues discovered that members of this class of germicides caused changes in gene expression, suggesting that Brain inflammation, a process also seen in people with autism and age-related cognitive disorde.
These chemicals stimulate the production of free radicals and damage microtubules, which are part of neurons and are important for cell division, the transport of chemicals between cells and maintaining cell sha.
The agricultural industry has been using Aslida and related coccidioside fungicides since the mid-1990s and has used 1,000 tons on vegetable, nut, potato, fruit and grape crops, as well as grains and lawns in the United Stat.
Later, AZ was added to a specific brand of mildew-resistant wallboard, which is now commonly used in residential and commercial buildin.
Over the past decade, several experimental studies have identified the potential for AstraZeneca to cause developmental and neurotoxici.
As a result of these studies showing that AstraZeneca is toxic at the embryonic stage, scientists have identified it as a major front-line target chemical for biomonitoring in the United Stat.
Zylka's lab, led by first author Wenxin Hu, PhD, a postdoctoral researcher at the University of North Carolina at Chapel Hill, measured concentrations of a biomarker of AZ exposure (AZ-acid) in the urine of pregnant women, along with a panel of In the urine of children 40 - 84 months o.
The experiments further found that AZ crosses the placenta into the developing brain of mouse embryos and is transferred to offspring during lactati.
"Azostrobin was found in house dust, with some samples showing high concentrations," Zirka sa.
