Science unexpected new discovery: cancer cells use genetic tricks to escape the immune system

Hundreds of cancer-related genes play different roles in the pathogenesis than scientists expected

It has long been known that so-called tumor suppressor genes can prevent cell growth and prevent the spread of cancer cells

Now, the team of Stephen Elledge, a researcher at the Howard Hughes Medical Institute, has discovered a surprising new role for many of these defective genes

The relevant research was found in Science on September 16, 2021

The traditional view is that for the vast majority of tumor suppressor genes, mutations can cause cells to grow and divide wantonly, beyond control

Elledge's new paper provides some answers

"These results reveal an unexpected relationship between tumor suppressor genes and the immune system," said HHMI researcher Bert Vogelstein (who was not involved in the study)

Clear melanoma

Of course, the idea that tumors can evade the body's defense system is not new

Checkpoint inhibitors are now big sellers

CRISPR technology

Elledge has a hunch that defective tumor suppressor genes are not just accelerating cell growth

Genetic analysis revealed abundant mutant genes in tumors and may play a role in tumor formation

Elledge's method reveals many different genes, and tumors can mutate to escape the body's defenses

Their research paints a thought-provoking picture of a rapid and fierce evolutionary arms race between cancer cells and the immune system.

In general, Elledge hopes that his discovery will open a new door to the treatment of cancer

Original search:

Timothy D.

DOI 10.