Science: Three different immune responses were revealed in patients with more severe COVID-19.

In a new study, researchers at the Perelman School of Medicine at the University of Pennsylvania found that three different immune responses to infections may help predict the trajectory of disease in severely ill patients and may ultimately inform how best to treat themThe findings were published online this month in the journal "The picture is from"There's not just one way to respond to the immune system in hospitalized patients," said the paper's co-author, DrDrDrPerelman School of Medicine, University of Pennsylvania, who is in charge of the system's department of pharmacology and translational therapyThere are a lot of heterogeneousities that we put into what we call the three 'immune types()We hope that we may actually be able to predict or at least infer different immune patterns in patients based on clinical dataThis will allow us to start thinking about having patients participate in different types of clinical trials"This coronavirus triggers different immune responses and symptoms in severe patients, but little is known about how the two correspond, which makes treatment decisions more difficult." Although recent studies have revealed the details of the immune response to the virus, most are single-case reports or concentrated in a small group of peopleAs far as these authors know, this is the first study to provide a comprehensive immune spectrum for a large number of hospitalized patientsThe researchers used in-depth immunoassay techniques to capture individual responses in patients during infectionThe study included inpatients, non-residents and health donors who were not infected at the University of Pennsylvania hospitalThere are different immune responses between different groups, but some models have clinical prospectsThe first type of immunology has strong cell activity as well as moderately activated cells and peripheral blood lymphocytesAs the main inflammatory immune cells and cells can be used to remove the virus The main feature of the second type of immunotype is the moderate activation of a portion of cells called cells and cells, as well as cells, memory cells, and peripheral blood lymphocytes The third type of immune type shows little evidence of an immune response to this infection The researchers then combined this in-depth immunoassay with clinical data to understand the relationship between immune response and disease The first type of immune type is associated with more serious diseases including inflammation, organ failure and acute kidney disease The second type of immunology is not related to the severity of the disease but to pre-existing immunosuppression and mortality The third type of no immune activation is independent of specific symptoms or clinical characteristics although they differ These immune types developed by his team represent adaptive immune responses A second study by researchers from the University of Pennsylvania reveals new details about the innate response The results of the study were recently published in the journal " "Cell and cell activity is determined by innate immune responses," said Dr Ph.D., co-author of the second study and a professor of microbiology at the University of Pennsylvania's Perelman School of Medicine We believe that the innate response of the immune system may be the cause of these three immune types identified by the laboratory "The researchers analyzed blood samples from patients with infection (moderate and severe illness) and healthy donors and found that the immune adaptive response had similar heterogeneity: strong activation of cells, cells, cells, and peripheral blood cells such as neutrophils, mononucleosis, and natural killer cells Although congenital reactions are also heterogeneous, the researchers observed that in patients with more severe disease, the surface and molecules of neutrophils reduced the molecular decline of natural killer cells (), immature granulocytes, and mononucleoblasts on the surface These two molecules are known to play an important role in the immune system's response to viral infections and are potential targets for immunotherapy How they drive and exacerbate adaptive responses in these three immune types is an important question that scientists are trying to better understand As research moves at an unprecedented rate, scientists are teaming up to find answers In many efforts, the University of Pennsylvania has assembled laboratory and clinical research teams from different backgrounds to increase the focus on the immune system and work with the processing department to manage the specimens to be analyzed "Understanding the power of the immune system to regulate its response to disease is one of the major advances in medicine over the past decade that the University of Pennsylvania has been at the center of this discovery," said Dr Dr We are now applying the extensive expertise and experience of our immunological team to research and treatment The deep immunoassay techniques used by these researchers in the first study are useful not only for today's disease, but also for many other diseases in the future "() "" References: