Science: the love and love between prkd2 and BCL6 control the production of TFH cells, and it is expected to develop new methods for the treatment of autoimmune diseases

February 1, 2020 / Biovalley BIOON / - -- in a new study, researchers from the Southwestern Medical Center of the University of Texas identified genes responsible for controlling the activity of T-follicular helper cells (TFH) Relevant research results were published in the Journal of science immunology on January 24, 2020 The title of the paper is "mutual infection between prkd2 and BCL6 controls T follicular helper cell differentiation" In this paper, they describe their research on prkd2 and their understanding of its role in autoimmune diseases Picture from science immunology, 2020, DOI: 10.1126/sciimmunologol.aaz0085 Previous studies have shown that abnormal behavior of TFH cells, a specialized T cell, can lead to immune response problems, which can lead to autoimmune diseases This is because TFH cells help B cells produce antibodies In the new study, the researchers identified prkd2, a gene responsible for producing an enzyme that controls TFH activity In light of the speculation that prkd2 plays a role in the production of autoimmune diseases, these researchers conducted genetic screening on mice mutated by ENU They found that mice with prkd2 mutations developed hypergammaglobulinemia They then found that a loss of function mutation reduced the production of prkd2 w807r, which controls TFH cell behavior Without this enzyme, there would be too many germinal centers in TFH cells, which would lead to the increase of B cell activity This leads to an increase in the production of IgE antibodies, which are common in patients with autoimmune diseases The researchers also found that the introduction of a protein called BCL6, a known gene expression repressor, directly into T cells of mice carrying the loss of function mutation also triggered over production of TFH cells They found that if the mice were immunized with BCL6, the protein tended to inhibit the expression of prkd2 in TFH cells, thus promoting them to mature faster By studying this process more carefully, these researchers found that prkd2w807r binds to BCL6 and phosphorylates BCL6 as part of the regulation of TFH cells, and its expression can inhibit the nuclear transport of BCL6 Removal of prkd2 allows unrestricted nuclear transport of BCL6 and leads to over activation of TFH cells The researchers point out that this over activation can lead to autoimmune diseases and allergies If they find compounds that increase prkd2 activity, they think they may be used to treat these two types of diseases (BIOON Com) reference: 1 Takuma Misawa et al Mutual infection between prkd2 and BCL6 controls T follicular helper cell differentiation Science immunology, 2020, doi:10.1126/sciimmunol.aaz0085 2.Gene responsible for controlling activity of T follicular cells identified https://medicalxpress.com/news/2020-01-gene-responsible-follicular-cells.html