Science: the energy source of cell division

When a cell divides, it goes through a series of complex events The mitochondria of the cell's power plant are the main energy source of these processes: they convert food into energy available to the cell Now a team led by biochemist Dr Angelika harbauer and professor Chris meisinger from the University of Freiburg in Germany has found a signal pathway linking these two key tasks: cell division and energy conversion Their research was published in the November 28 issue of science When a cell divides, its genetic information is copied in a complex process called mitosis and distributed to the resulting daughter cells This process is controlled by a special protein called cyclin dependent kinases As the name suggests, these cyclin dependent kinases are regulated by cyclins At each stage of cell cycle, there are other proteins that periodically form and re decompose Mitochondria are the main energy source of all these processes In baker's yeast experiment, harbauer found that at the beginning of mitosis, a cyclin dependent kinase phosphorylated a mitochondrial protein, tom6, which means that the kinase modified tom6 and activated it Tom6 is a component of the mitochondrial protein entry valve: it is responsible for the input of all proteins that function in mitochondria Harbauer confirmed that this cell cycle dependent modification of the protein entry valve resulted in increased protein input This improves the performance of mitochondria as a cell power plant, thus ensuring that complex events such as cell division can obtain enough energy If this protein entry valve modification does not occur, the cell division process and eventually cell growth will slow down "We also found this modification in yeast in the human body So it's very likely that this new signaling pathway also connects cell energy factory performance and cell division in human cells, "meisinger said Meisinger is now planning to analyze these mechanisms in tumor tissue In many forms of cancer, the performance of mitochondria is greatly reduced This new signal pathway may be the key to elucidate the relationship between mitotic disorder and mitochondria Original search:
Angelika B Harbauer, Magdalena Opalińska, Carolin Gerbeth, Josip S Herman, Sanjana Rao,Birgit Sch?nfisch, Bernard Guiard, Oliver Schmidt, Nikolaus Pfanner, and Chris Meisinger Cell cycle–