Science: subverting textbook knowledge for the first time, we found that DNA is not transcribed

January 4, 2015 / BIOON/ --To open any biology textbook, the first thing we need to learn is that the DNA of the body can give instructions to make proteins, and proteins play an important role in the development of various functions of the body Recently, a research paper published in the international journal Science, researchers from the University of Utah, through research, revealed for the first time that amino groups are used to make proteins Acid can be assembled without DNA instructions and messenger RNA information, the study may change the textbook version of protein production Researcher Peter Shen said the research is very meaningful, and it also reflects the broad and profound field of biology Ribosome is a protein assembly machine, which can connect different amino acids according to special genetic code Sometimes when ribosome goes wrong, it will stop the assembly of proteins In this study, researchers revealed a new role of a protein called rqc2, which exists in the body from yeast to men, and is recycled in incomplete proteins Previously, rqc2 promoted ribosome to continuously add two alanine and threonine (20 in total) to incomplete proteins The role of rqc2 is similar to that of messenger RNA The truncated protein is like a semi-finished car Although it seems strange to carry random alanine and threonine, and it can not function normally, this meaningless amino acid sequence is playing a special role The researchers discovered rqc2 protein by means of the technology called low temperature electron microscopy, while later researchers revealed that rqc2 / ribosome complex can add amino acids to the stagnant protein by using the new RNA sequencing technology, because rqc2 / ribosome complex can also combine with tRNAs, and tRNAs is a structure that can bring amino acids into the protein, especially Different tRNAs can carry alanine and threonine In the end, Frost said, our research has found a new type of protein, and we believe that we can analyze more functions of this new type of protein more clearly through later in-depth study This article is the original compilation of Biovalley, welcome to reprint! Please indicate the source of the reprint and attach the original link Thank you!