Science subjournal: Central South University develops natural halloysite nanotubes to deliver small interfering RNA for bladder cancer treatment

October 17, 2019 / Bio Valley bio on / -- RNA interference (RNAi) technology can specifically silence the expression of target genes, which is a promising cancer treatment method Recently, researchers from the Department of Urology, the Third Xiangya Hospital of Central South University and the prostate disease Research Institute of Central South University found that natural halloysite nanotube (hNT) can assist in the delivery of an active small interfering RNA (siRNA) targeting receptor interacting protein kinase 4 (ripk4) ）It can effectively inhibit its expression to treat bladder cancer Photo source: science advanced researchers found that HNTs / siRNA complex increased the serum stability of siRNA, increased its circulating life in the blood, and promoted the cell uptake and tumor accumulation of siRNA SiRNA significantly down regulated the expression of ripk4 in bladder cancer cells and bladder cancer tumors, thus inhibiting the tumor development of three bladder cancer models (subcutaneous model, in situ bladder tumor model and lung metastasis model), without adverse reactions Therefore, the researchers found a simple and effective method of using ripk4 to silence and inhibit bladder cancer, which is a promising treatment for bladder cancer Reference: Jianye Liu et al Delivery of ripk4 small interfering RNA for blade cancer therapy using natural halloysite nanotubes Science advances 25 SEP 2019: Vol 5, No 9, eaaw6499 doi: 10.1126/sciadv.aaw6499