Science sub-newsletter breakthrough! A two-parent peptide kills HIV-1 virus particles and infected cells!

, June 16, 2020 /
PRNewswire/
--HIV-related morbidity and mortality has declined significantly as a result of combined antiretroviral therapy, but HIV is vulnerable to mutation and drug resistancethe development of antiviral drugs for previously undetermined targets is essential for the treatment of existing drug-resistant HIV strainsSome polypeptides (Env, gp120-gp41) from HIV-1 envelopegin have been shown to be effective in suppressing HIV-1 infection、、HIV,,Science Translational Medicine,"An amphipathic peptide targeting the gp41 cytoplasmic tail kills HIV-1 virions and infected cells"。Picture Source:Science Translational Medicineresearchers identified from the cytoplasm region a peptide F9170 that effectively inactivates HIV-1 virus particles, induces HIV-1 infection cells necrosis, and reactivates latent lysoping cells, which are effective against free virus particles or HIV-infected cellsfurther studiesfound that F9170 specifically targeted the conservative HIV-1 Env cytoplasm tail, effectively destroying the integrity of the virus membraneShort-term single-administered F9170 can control the viral load, making it lower than the detection limit of chronic SHIV-infected macaquesThe researchers also found that F9170 can enter the brain and lymph nodes, one of the latent areas of HIVAs a result, the researchers believe that F9170 could be a candidate for AIDS treatmentBioValleyBioon.com)References:Qian Wang et al.
An amphipathic peptide target target ing the gp41 cytoplasmic tail kills HIV-1 virions and infected cells.
Science Translational Medicine 03 Jun 2020: Vol12, Issue 546, eaaz2254 DOI: 10.1126/scitranslmed.aaz2254