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【Science Sub-Journal】Study finds that circadian clock disturbance can directly accelerate the progression of colorectal cancer!

 Last Update: 2022-08-20
 Source: Internet
 Author: User

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This article is original from Translational Medicine Network, please indicate the source for reprinting

Author: Sophia

Introduction: An alarming increase in the incidence of colorectal cancer (CRC) in young adults has been reported; however, the underlying molecular mechanisms remain undefined

The study, titled "Disruption of the circadian clock drives Apc loss of heterozygosity to accelerate colorectal cancer," was published Aug.

Background

According to the National Institutes of Health, there has been an alarming rise in the incidence of early-onset colorectal cancer among young adults

"As a society, we are chronically exposed to several environmental factors that affect our biological clocks, including night shift work, prolonged light exposure, changes in sleep/wake cycles and changes in feeding behaviors," said Selma Masri, assistant professor of biochemistry at the UCI School of Medicine.

Research progress

During the study, the scientists developed a novel tissue-specific genetically engineered mouse model (GEMM) to define the molecular pathways linking circadian disruption and CRC pathogenesis

Research result

In this study, researchers found that both genetic disruption and environmental disruption of the circadian clock contribute to mutations in the adenomatous polyposis Escherichia coli (APC) tumor suppressor, which is found in the vast majority of human colorectal cancers (CRCs).

APC mutations are also associated with second hits in key oncogenic pathways, including Kras, Braf, p53 and Smad4, that drive adenocarcinoma progression, collectively promoting disease progression

Significance

The biological clock is an internal biological pacemaker that controls many physiological processes

References:

https://phys.

This article is intended to introduce the progress of medical research and cannot be used as a reference for treatment plans

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