Science Sub-journal: Study reveals mechanisms for HIV escape treatment

2020 May 15 News / BioValley BIOON / --- According to researchers at Yale University published in the "ScienceTranslationalMedicine" magazine May 13, for AIDS patients, even successful antiretroviral therapy, HIV can still be hidden in a dormant state in decades of immune system cells, and re-emergence of the threat to the lives of patientsNow, researchers at Yale University have discovered a molecular mechanism on how to accomplish this virus hidden skillsa (Source: Www.pixabay.com)CD4T cell longevity haven HIV, HIV can be by genomic DNA and the integrated T cell genome, and therefore escape the immune system recognitionHowever, since the virus is now in the inactive state, thus leaving no trace to mark its locationauthor of the article, microbial pathogenesis and medicine (infectious diseases), assistant professor Ya-ChiHo said: "HIV will integrate itself into the human DNA, and therefore antiretroviral therapy can not find it and kill these cells are very researchdifficulties, only 1.004 million parts per CD4T cells have a characteristic of having HIV infection"
in this regard, the research team at Yale University have developed a way to find these hidden infected cells, and can be controlled spread of the virusHo team extracted from cells received antiretroviral therapy in HIV patientsScientists in a laboratory dish of activated T cells with the virus, and using a fluorescent probe labeled viral RNA recognition of infected cellsThen they removed these rare HIV-infected cells, and high-resolution study of individual cellsThis method is called HIVSortSeq enable researchers to track the interactions between a single host cell RNA virusesThey found, HIV hijacked allow substantially T cell survival geneThe researchers said that, interestingly, HIV is committed to the promotion and expression of genes related to cancer Essentially, HIV control of gene activation control these cancers from the host cell The researchers said that although the process does not cause cancer in T cells, but this process may contribute to these HIV-infected T-cell proliferation researchers say that understanding of these processes can help scientists new ways to control HIV infection to develop (Biovalley Bioon.com) Information Source: ResearchersdiscoverhowHIVhidesfromtreatment Original source: R.Liuelal, "Single-celltranscriptionallandscapesrevealHIV-1- drivenaberranthostgenetranscriptionasapotentialtherapeutictarget, "
ScienceTranslationalMedicine (2020) .stm.sciencemag.org / lookup / doi / .. scitranslmed.aaz0802