Science Sub-Journal: Short pressure skin can deliver drugs! Singapore scientists develop new painless methods!

The transmission of the toned drug uses chemical, physical, or biochemical enhancers to cross the skin barrier.
over the past few decades, chemical and biochemical enhancement technologies have been developed to destroy the horn layer (SC) used to transport large hydromassage drugs.
another technology worth mentioning is the micro-needle (MN), medical beauty is also a "home-cooked dish."
however, due to their small size, the amount of drugs that can be delivered is usually in the microgram range.
technique is ultrasonic-mediated TDD, which produces acoustic oscillating pressure waves.
although ultrasound-mediated TDD has been shown to be effective, it is limited by complex mechanical equipment and associated skin tissue heating, which can damage deeper tissue.
, simple, low-cost and minimally invastible TDD technology is still needed to make it easy for patients to get through the skin.
scientists from Singapore's Nanyang Technological University (NTU) and the Institute of Science, Technology and Research (A-STAR) have discovered a new way of delivering drugs that can be delivered to the skin of "temporal pressure" mice.
the study was published in Science Advances.
needles and micro-needle injections can damage the skin, but micro-pores are not common, can be painless through the skin to transport insulin and other drugs.
the study was inspired by the traditional Chinese medicine "push-and-take" therapy, in which doctors rub and apply pressure to skin and muscle tissue and then apply an external cream.
the researchers put the two magnets together so that they pinch together to apply pressure to the folds of the skin, causing short-term changes in the skin barrier, especially the formation of "micro-holes" beneath its surface.
, they found that the microholes covered an area of about 3 microns, making the drug applied to the skin surface easier to spread.
the micro-porous drug spread six times between the skins of mice that did not receive instantaneous stress therapy.
researchers further tested the delivery of insulin in mouse skin in a new way, reducing skin damage and pain caused by the delivery of drugs through the skin.
results show that nanoparticles and insulin can be effectively transmitted through the skin of mice, with a molecular weight of up to 20,000 Daltons.
this is 40 times the maximum mass (40 Daltons) currently reported in the scientific literature for the delivery of tyrospidic drugs (i.e., through patches).
the amount of drugs delivered through "short pressure" can also be comparable to the amount of drugs delivered by micro-needle patches.
dozens of needles on micron patches are smaller than the width of a human hair made from biocompleive compounds and are typically used to deliver a small amount of drug time through the skin to the skin.
Compared to the traditional risk of necessary penetration of the skin and hypoglycemia (traditionally insulin injections act too quickly and patients become dizzy), this new method slowly releases the drug over time without damaging the skin, thereby reducing pain.
, the team also found that, through their methods, cells in the skin layer (epiderm) were observed to increase the number of "gap connections" and the number of "tight connections" decreased.
these connections control the number of molecules passed between cells: if the expression of gap connections increases, more molecules can pass through the cell barrier, while tight connections limit the movement of molecules outside the cell.
In animal experiments, two magnets were used to apply pressure to the back skin of mice for one to five minutes, depending on how quickly the drug was delivered, then removed and then partially applied like frost.
team hypothesed that one minute would be sufficient for drugs that require slower or smaller doses, and five minutes for faster drugs.
then place the drug for 12 hours and then image the skin with a fluorescence microscope to see how much the drug penetrates the skin.
team compared three types of skin: stressed skin, unstressed skin, and skin delivered with microns.
skin treatment pressure had to be found to be similar to the amount of medication delivered through the skin and micro-needle patches, while the pressure skin without treatment had significantly fewer drug deliveries.
they also observed that the microholes disappeared the day after they were formed, indicating that skin cells had filled the voids.
Professor David Laurence Becker of the LKC Medicine at Nanyang Technological University in Singapore, who specializes in tissue repair and regeneration, says his paper highlights the potential of using this method, which reduces the need for diabetics to inject insulin multiple times a day using traditional needles and syringes.
the new findings offer hope for patients with diabetes and others, researchers will further refine this approach, making it possible one day to deliver enough drugs through the skin through a patch and get rid of routine injections.
: Source: Translational Medicine Network !-- end of content presentation -- !-- determine whether the login ends.