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September 30, 2020 /--- In a new study, researchers from research institutions such as the University of Manchester in the United Kingdom have found that monocytes (a type of white blood cell) released from bone marrow to the blood have abnormal characteristics in people with COVID-19, and are more severe in patients with severe infections.
study was recently published in the journal ImmunoSciencelogy under the title "Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19".
images from Science Immunology, 2020, doi:10.1126/sciimmunol.abd6197.
by detecting abnormal monocytes early, doctors may be able to predict which patients are more likely to develop severe COVID-19.
study provides the strongest evidence yet that monocytes may be important targets for COVID-19 therapy.
, however, the researchers say it's unclear whether abnormal monocytes are released from the bone marrow or changes that occur when they enter the bloodstream.
, treatments that prevent their release from the bone marrow may help reduce the over-immune response that leads to adverse outcomes in patients with severe COVID-19.
have known that monocytes -- the largest types of white blood cells -- are an important part of the lungs during infection and play a role in conservation and repair.
the researchers analyzed more than 100 blood samples from COVID-19 patients admitted to four hospitals in Greater Manchester to look for biomarkers that indicated progression towards serious illness at different points during their stay.
Co-author dr John Grainger, of the University of Manchester, said: "Our study re-emphasizes the importance of the inno-immune system in COVID-19, and we are pleased to finally share our findings and hope it will better provide information for the treatment of this devastating disease."
" (bioon.com) Reference: 1. Elizabeth R. Mann et al. Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19. Science Immunology, 2020, doi:10.1126/sciimmunol.abd6197.2. Role of bone marrow immune cells in COVID-19 revealed.
