Science Sub-Journal: Providing a "wake-up service" for the immune system may effectively eliminate tumors in the body!

According to the latest global cancer burden data released by the International Agency for Research on Cancer ( IARC ) of the World Health Organization in 2020 , there will be 4.
57 million new cancer cases and 3 million deaths from cancer in China in 2020.
This number is shocking! For cancer, on the one hand, we must prevent it , and on the other hand, we must speed up the pace of research to find a way to overcome tumors as soon as possible .

According to the latest global cancer burden data released by the International Agency for Research on Cancer ( IARC ) of the World Health Organization in 2020 , there will be 4.

57 million new cancer cases and 3 million deaths from cancer in China in 2020.

Tumor immunotherapy is a treatment method that stimulates the body's own immune system and restores the body's normal anti- tumor immune response, thereby controlling and eliminating tumors

How to make the immune system notice the tumor cells? Researchers from the Massachusetts Institute of Technology launched a study on this, and finally discovered a new way to wake up the immune system to attack tumors

DOI : 10.

1126/scisignal.

DOI : 10.

In this study, the researchers etoposide ( Etoposide treatment) tumor cells in vitro, to obtain DNA of tumor cell damage, and it is then injected into a cancer tumor in vivo in mice, systemic checkpoint inhibitor Used in combination

The reason for in vitro treatment to obtain damaged tumor cells is that if the drug is injected directly into the body, T cells and dendritic cells will also be severely damaged, and there will be no enhanced immune response and increased survival rate of mice.

In order to prevent the drug from damaging T cells and dendritic cells, it is necessary to clean the tumor cells treated with Etoposide and then inject them into the tumors of cancer-bearing mice

Figure: After the combined use of damaged tumor cells and systemic checkpoint inhibitors, the survival rate of cancerous mice is improved

Figure: After the combined use of damaged tumor cells and systemic checkpoint inhibitors, the survival rate of cancerous mice is improved

Figure: After the combined use of damaged tumor cells and systemic checkpoint inhibitors, the tumor area in mice is significantly reduced

Figure: After the combined use of damaged tumor cells and systemic checkpoint inhibitors, the tumor area in mice is significantly reduced

This shows that damaged tumor cells can be used as an effective adjuvant, combined with systemic checkpoint inhibitors, to activate T cells to participate in the immune response, wake up the immune system, and promote effective anti-tumor immune responses
.

This shows that damaged tumor cells can be used as an effective adjuvant, combined with systemic checkpoint inhibitors, to activate T cells to participate in the immune response, wake up the immune system, and promote effective anti-tumor immune responses
.

In addition, the researchers also found that mice cured by this treatment would not develop tumors even if they injected tumor cells into their bodies
.

In contrast, injecting tumor cells into healthy mice, the tumor area reached 200mm2 within 30 days .

In addition, the researchers also found that mice cured by this treatment would not develop tumors even if they injected tumor cells into their bodies

Figure: Mice treated with combination therapy, even if tumor cells are injected into their bodies, they will not develop into tumors

Figure: Mice treated with combination therapy, even if tumor cells are injected into their bodies, they will not develop into tumors

This result indicates that the combination of damaged tumor cells and systemic checkpoint inhibitors may induce effective anti-tumor immune memory.

When such tumor cells reappear in mice, T cells will accurately recognize tumor cells and produce Effective anti-tumor immune response, remove tumor cells and prevent tumor development

This result indicates that the combination of damaged tumor cells and systemic checkpoint inhibitors may induce effective anti-tumor immune memory.

In conclusion, this study shows that tumor cells with damaged DNA can be used as an immune enhancer, combined with systemic checkpoint inhibitors, to effectively wake up the immune system, produce an effective anti-tumor immune response, and eliminate tumors in the body
.
At present, this experiment is only an animal experiment, and clinical trials are needed to test its efficacy, but this method may be suitable for patients who have failed conventional treatment programs or developed acquired drug resistance
.
It is hoped that clinical trials can be put on the agenda as soon as possible to benefit more patients
.

Reference materials:

[1]https:// https://medicalxpress.
com/news/2021-10-cancer-treatment-reawaken-immune.
html

[2] https://medicalxpress.
com/news/2021-10-cancer-treatment-reawaken-immune.
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