Science sub-journal! Chinese scientists develop high-performance cancer vaccine seispheted with new microcapsules!

, June 19, 2020 /PRNewswire/-- The development
of safe and effective biologics using approved materials and clever design can accelerate the clinical transformation processscientists at the Institute of Process Engineering of the Chinese Academy of Sciences have developed a new therapeutic tumor vaccine based on self-healing polylactic acid microcapsules, which can effectively activate the immune system and inhibit theoftumorsThe study was published May 22 in the journal Science AdvancesTherapeutic cancer vaccines thatuse the immune system to kill cancer cells have a huge prospect intumortreatmentPhoto Source: WEI Wei
The research team is led by Ma Guangguang, a biodote and biomaterials team of the National Key Laboratory of Biochemical Engineering of the Chinese Academy of Sciences, who has designed and produced a variety of tumor vaccines in their early workThese vaccines have been shown to be effective in differenttumormodels, such as lymphoma, melanoma andbreast cancer however, due to certain limitations, researchers were forced to improve early tumor vaccine For example, Professor Ma says poor immune microenvironments, complex preparation processes and frequent vaccinations have seriously affected their performance "So we designed a new formula based on microsacs for high-performance cancer vaccinations, " says Professor Ma "
study is the first time that researchers have used self-healing microcapsules with post-encapsulation, multiple loading, and effective regulation of immune microenvironments in tumor vaccine this special self-healing characteristic provides a mild and effective example of antigen microcysticization After inoculation, these microsacs create a good immune microenvironment in situ, where antigen release dynamics, recruiting cell behavior, and acidic environments work together because of synergy, the vaccine successfully improved antigen utilization, improved antigen presentation, and activated antigen profile cells "In different tumor models, different types of antigens can produce effective T-cell responses, effectively inhibit tumor , anti-metastasis, and prevention of postoperative recurrence," Wei said "
, in addition, the researchers demonstrated the effectiveness of the new vaccine platform used by the new antigen vaccine, which is consistent with precision medicine Because of the simple process after encapsulation, clinicians can prepare new antigen preparations at any time a peer reviewer in the journal Science Advances called the study a "comprehensive and rational design." The reviewer also stressed that the results were "impressive" and that the work was "highly valuable for therapeutic vaccines and cancer immunotherapy" (BioValleyBioon.com) References: "
Self-healing microcapsules Synergetically modulate the microenvironment for potentcancer cancer " Science Advances (2020) DOI: 10.1126/sciadv.aay7735
.