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According to the amount of sugar in the food, people divide it into three categories: high-sugar, low-sugar and no-sugar foods
.
Foods with high sugar content mainly include edible sugar and various grains (milk tea is high in sugar)
.
A high-sugar diet can significantly increase the risk of chronic diseases such as diabetes, hypertension, and kidney disease, and accelerate aging
.
In addition, patients with schizophrenia (SZ) and bipolar disorder (BD) on a high-sugar diet have more severe clinical symptoms
.
Advanced glycation end products (AGEs) are the combination of excess sugar and protein, which can induce inflammation and oxidative stress in tissues
.
Glyoxalase 1 (GLO1) is an enzyme that can remove the toxic by-products accumulated by cells during glycolysis, and can protect cells from the toxic effects of AGE
.
GLO1 expression is reduced in patients with schizophrenia (SZ) and bipolar disorder (BD)
.
On November 10, 2021, the Haruo Okado research team of the Department of Neuroscience, Tokyo Metropolitan Institute of Medical Sciences found that aspirin, an antipyretic and analgesic, can alleviate cerebral vascular disease caused by high-sugar diets, and reverse hyperactivity, repetitive stereotyped behaviors, cognitive learning disorders and other spirits Neurological behavior abnormalities
.
The researchers set up four groups: normal mice receiving starch diet, normal mice receiving sucrose diet, GLO1 knockout mice receiving starch diet, GLO1 knockout mice receiving sucrose diet, adolescent mice Feeding for 50 days, sucrose diet alone or GLO1 knockout alone did not cause abnormal behavior in mice, but GLO1 knockout mice on sucrose diet showed cognitive and memory impairment, repetitive stereotyped behavior, hyperactivity and other abnormal behaviors
.
This suggests that environmental factors (sucrose diet) and genetic factors (knockout GLO1) interact to cause psychosis-like behavior
.
The extracellular glucose concentration in the PFC brain area of normal mice on starch diet increased after one hour of eating, and dropped to the baseline level within 2 hours
.
The GLO1 knockout mice on sucrose diet did not increase the extracellular glucose concentration after eating, and there was a glucose uptake disorder
.
There is an imbalance of dopamine regulation between the medial prefrontal cortex (mPFC) and the striatum in schizophrenia
.
The dopamine release from the striatum of GLO1 knockout mice on a sucrose diet increased, and the number of inhibitory neurons in the brain region of mPFC was reduced by small albumin
.
D2 receptor agonists can reduce the level of dopamine in the striatum of GLO1 knockout mice on a sucrose diet and improve hyperactivity disorder
.
Immunofluorescence experiments found that GLO1 is expressed on microglia, astrocytes, endothelial cells and neurons, with the most expressed on astrocytes
.
In addition, the expression of AGE on endothelial cells of GLO1 knockout mice on sucrose diet increased, and the activation of microglia increased, which promoted the transition of astrocytes to a pro-inflammatory state
.
At the same time, GLO1 knockout mice on a sucrose diet increased capillary fibrin deposition and vascular disease
.
Aspirin is a non-steroidal anti-inflammatory drug, which mainly exerts antipyretic, analgesic, anti-rheumatic, and anti-platelet aggregation effects
.
Researchers found that low-dose aspirin can completely alleviate hyperactivity, repetitive stereotyped behaviors, cognitive learning disabilities in GLO1 knockout mice on a sucrose diet, and reduce fibrin deposition, partially alleviating glucose uptake
.
In general, this article found that adolescent high-sugar diet causes abnormal deposition of brain capillary fibrin, induces neuroinflammatory reactions, and ultimately causes abnormal mental behavior in adulthood
.
[References] High-sucrose diets contribute to brain angiopathy with impaired glucose uptake and psychosis-related higher brain dysfunctions in mice The pictures in the text are from the references
According to the amount of sugar in the food, people divide it into three categories: high-sugar, low-sugar and no-sugar foods
.
Foods with high sugar content mainly include edible sugar and various grains (milk tea is high in sugar)
.
A high-sugar diet can significantly increase the risk of chronic diseases such as diabetes, hypertension, and kidney disease, and accelerate aging
.
In addition, patients with schizophrenia (SZ) and bipolar disorder (BD) on a high-sugar diet have more severe clinical symptoms
.
Advanced glycation end products (AGEs) are the combination of excess sugar and protein, which can induce inflammation and oxidative stress in tissues
.
Glyoxalase 1 (GLO1) is an enzyme that can remove the toxic by-products accumulated by cells during glycolysis, and can protect cells from the toxic effects of AGE
.
GLO1 expression is reduced in patients with schizophrenia (SZ) and bipolar disorder (BD)
.
On November 10, 2021, the Haruo Okado research team of the Department of Neuroscience, Tokyo Metropolitan Institute of Medical Sciences found that aspirin, an antipyretic and analgesic, can alleviate cerebral vascular disease caused by high-sugar diets, and reverse hyperactivity, repetitive stereotyped behaviors, cognitive learning disorders and other spirits Neurological behavior abnormalities
.
The researchers set up four groups: normal mice receiving starch diet, normal mice receiving sucrose diet, GLO1 knockout mice receiving starch diet, GLO1 knockout mice receiving sucrose diet, adolescent mice Feeding for 50 days, sucrose diet alone or GLO1 knockout alone did not cause abnormal behavior in mice, but GLO1 knockout mice on sucrose diet showed cognitive and memory impairment, repetitive stereotyped behavior, hyperactivity and other abnormal behaviors
.
This suggests that environmental factors (sucrose diet) and genetic factors (knockout GLO1) interact to cause psychosis-like behavior
.
The extracellular glucose concentration in the PFC brain area of normal mice on starch diet increased after one hour of eating, and dropped to the baseline level within 2 hours
.
The GLO1 knockout mice on sucrose diet did not increase the extracellular glucose concentration after eating, and there was a glucose uptake disorder
.
There is an imbalance of dopamine regulation between the medial prefrontal cortex (mPFC) and the striatum in schizophrenia
.
The dopamine release from the striatum of GLO1 knockout mice on a sucrose diet increased, and the number of inhibitory neurons in the brain region of mPFC was reduced by small albumin
.
D2 receptor agonists can reduce the level of dopamine in the striatum of GLO1 knockout mice on a sucrose diet and improve hyperactivity disorder
.
Immunofluorescence experiments found that GLO1 is expressed on microglia, astrocytes, endothelial cells and neurons, with the most expressed on astrocytes
.
In addition, the expression of AGE on endothelial cells of GLO1 knockout mice on sucrose diet increased, and the activation of microglia increased, which promoted the transition of astrocytes to a pro-inflammatory state
.
At the same time, GLO1 knockout mice on a sucrose diet increased capillary fibrin deposition and vascular disease
.
Aspirin is a non-steroidal anti-inflammatory drug, which mainly exerts antipyretic, analgesic, anti-rheumatic, and anti-platelet aggregation effects
.
Researchers found that low-dose aspirin can completely alleviate hyperactivity, repetitive stereotyped behaviors, cognitive learning disabilities in GLO1 knockout mice on a sucrose diet, and reduce fibrin deposition, partially alleviating glucose uptake
.
In general, this article found that adolescent high-sugar diet causes abnormal deposition of brain capillary fibrin, induces neuroinflammatory reactions, and ultimately causes abnormal mental behavior in adulthood
.
[References] High-sucrose diets contribute to brain angiopathy with impaired glucose uptake and psychosis-related higher brain dysfunctions in mice The pictures in the text are from the references
