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Science Sub-Journal: An Orthogonal IL-2/IL-2Rβ System Promotes Persistence of CAR-T Cells and Enhances Tumor Clearance

 Last Update: 2022-04-29
 Source: Internet
 Author: User

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Chimeric antigen receptor (CAR) T cells (CAR-T) induce durable responses in patients with refractory hematological malignancies

Interleukin-2 (IL-2) is an important cytokine that activates T cells and is considered a way to treat cancer

In a new study, researchers from Synthekine in the United States report an orthogonal IL-2 receptor/ligand system that can specifically control the proliferation and activation of CAR-T cells in vivo.

CAR-T cell manufacturing pipeline, image from Gene Therapy, 2021, doi:10.

T cells were genetically engineered to express the receptor hoRb, which can only be activated by STK-009

In a preclinical model of human CAR-refractory lymphoma, STK-009 treatment resulted in systemic and intratumoral proliferation and activation of hoRb-expressing anti-CD19-CD28ζ CAR-T cells (SYNCAR)

References:

Paul-Joseph Aspuria et al.

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