Science: Study reveals role of microbiome in fighting cancer

August 15, 2020 /--- In a recent study, researchers from the Sydney Institute of Chronic Diseases found that specific gut bacteria can help our immune system fight cancer.
this finding provides a new understanding of why immunotherapy has different effects on cancer treatment.
study, published recently in the journal Science, suggests that combining immunotherapy with specific microbial therapies enhances the immune system's ability to recognize and attack certain melanoma, bladder and colorectal cancer cancer cells.
Author Dr Kathy McCoy is working to harness the power of the microbiome to improve health and treat disease.
need to better understand the role of bacteria in regulating the immune system, says McCoy.
(Photo source: www.pixabay.com) "Recent studies provide strong evidence that gut bacteriocytes can positively affect anti-tumor immunity and improve the effectiveness of immunotherapy in the treatment of certain cancers, but how bacteria do this remains elusive, and we have been able to demonstrate how certain bacteria enhance the ability of T-cells."
, the researchers identified immunotherapy to treat bacteria associated with colorectal cancer.
, they used sterile mice as their subjects to introduce these specific bacteria with immuno-checkpoint blocking therapy, a cancer immunotherapy.
that specific bacteria are critical to the work of immunotherapy.
"We found that small molecules produced by these bacteria are important," said Dr. Lukas Mager, a senior postdoctoral researcher at McCoy Labs and lead author of the study.
" myosine interacts directly with T cells and improves the effectiveness of immunotherapy.
" researchers later confirmed the findings in bladder cancer and melanoma.
how microorganisms can improve immunotherapy is critical to designing anti-cancer therapies, which may include microorganisms," said McCoy, a professor of immunology.
we should fully understand how to use this new knowledge to improve the effectiveness and safety of anti-cancer therapies and to improve the survival of cancer patients.
.com Source: Researchers discover the microbiome's role in the original source of cancerous tumours: "Microbiome-derived inosine modulates response to checkpoint or science.sciencemag.org/lookup/ Science" (2020). 1126/science.abc3421.