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27, 2020 // In a study published in the international journal Science entitled "A programmable life-goal-level-the-cell-single-cell in yeast", scientists from the University of California and other institutions have worked to solve the key mechanisms behind the body's aging mystery, in which researchers found two different pathways in the aging process and devised a new way to program these processes to extend the body's lifespan.
Photo Source: Hao Lab, UC San Diego Our human life is determined by the aging of the body's cells, and to understand whether different cells age at the same speed and for the same reason, researchers have studied the aging of wine yeast, a manageable model used to study the mechanisms of aging, including the aging pathways of skin and stem cells.
researchers found that cells carrying the same genetic material and in the same environment age in very different ways, and their fate unfolds through different molecular and cellular trajectories, using microfluidics, computer models, and other techniques, and found that about half of the cells age as the stability of the nucleus decreases, a special region of the nucleus DNA that synthesizes key components that produce protein factories, compared with half of the cells that age due to mitochondria.
early in life, cells set foot on the path of nucleosomes or mitochondria and follow the body's aging pathway through aging and death throughout the life cycle, and in the control center, researchers found a major circuit that guides these aging processes, said researcher Nan Hao.
then researchers worked together to develop a new model of aging so that they could manipulate and ultimately optimize the aging model, and computer simulation technology could help researchers reprogram major molecular circuits by repairing DNA and develop an aging pathway that significantly prolongs the life of the body.
this study, researchers suggest the possibility of rationally designing genes or chemical-based therapies to reprogram human cell aging, with the goal of selectively slowing down human aging and extending human life.
future researchers will test the new model in more complex cells and organisms and eventually look for similar ways of aging in human cells, with plans to test chemical techniques and evaluate ways to guide the body's longevity by combining therapies with drug-mixed agents.
concluding that the results of this paper benefit from the ongoing efforts of a strong interdisciplinary team of researchers who not only modeled, but also conducted experiments to determine whether the model sbeing to be correct, and that these repetitive processes are also important for current and later researchers.
() References: 1) Researchers 2 discover s of aging and new insights on promoting healthspan 2 Yang Li1, Yanfei Jiang, Julie Paxman, et al. A programmable fate fate datingddes sing-cell aging in yeast, Science
17 Jul 2020: Vol. 369, Issue 6501, pp. 325-329 DOI: 10.1126/science.aax9552.