Science: Reveals the slight tactile mechanism of Messner's small body perception.

, June 27, 2020 /PRNewswire/ --bio-valleyBIOON/--- Meissner Corpuscle, also known as the tactile small body, is a mechanical sensory end organ densely distributed on the hairless skin of mammalsThe basic anatomical structure of the Messner small body and the mechanical sensory neurons that dominate its A-beta (larger cell diameter and rapid action potential conduction) have been widely describedHowever, little is known about the requirements of Mesner's small body and the A-beta mechanical sensory neurons that govern it in terms of tactile-related behavior, sensory motor ability, and tactile perceptionmice lacking brain-derived neurotrophic factors (BDNF) or their receptor TrkB had a range of developmental disorders, including a lack of Mesna small bodyResearchers from Harvard Medical School and Stanford University in the United States concluded that limiting TrkB manipulation to sensory neurons combined with selectivegeneticmarkers would allow them to study the developmental assembly of Messner's small body and its function in the body's sensationsWhen studying the development of Messner's small body, they found that there were two types of A-beta mechanical sensory neurons that dominate mesna small bodyThey assessed the requirements for haptic sensitivity and fine sensory motion control of messaly small bodies, as well as the anatomical, physiological, and microstructure properties of the two A-beta mechanical sensory neurons that govern the mechanical sensory end organsThe findings, published in the June 19, 2020 issue of The Journal of Science, are entitled "Meissner Corpuscles and their spatially intermingled afferents underlie gentle gentle sitper siton."images from Science, 2020, doi:10.1126/science.abb2751sensory neuron-specific knockout of TrkB resulted in the complete loss of Messner's small body, without affecting other mechanical sensory end organs in the hairless skin of mice, including the A-beta mechanical sensory neuron-Merkel-Merkel cell complex and the Pacinian corpuscle, also known as the ring-layer small bodyBehavioral measurements showed that mice without Mesna had defects in their perception, response to the slightest detectable force that acts on hairless skin, and fine sensory movement controlgeneticmarker syllas show that mesner is dominated by different A-beta sensory neurons on two types of molecules: one for TrkB and the other for tyrosine kinase Ret Although the two types of A-beta neurons react differently to tactile stimuli, the two Types of Beta Neuronreact seismo-positive (TrkB-plus) are more sensitive to the introduction of the Messner small body, both when it starts and shifts in the trapezoidal indentation of the hairless skin, while the introduction of the Ret-Mesna small body is less sensitive and rarely reacts when the trapezoidal indentation is shifted Some Ret-plus neurons respond continuously even when static indentation is stimulated In addition, the ends of axons of these two A-beta mechanical sensory neurons were found to be homogenous tiled, but heterogeneous offsets Computational modeling shows that this anatomical arrangement maximizes the available information for coding acuity, while ensuring that a limited number of neurons are fully covered with the skin Finally, ultra-microstructure analysis using electron microscopes showed that the more sensitive TrkB-Mesna small body incoming axon endings had a larger number of flaky cell wraps than the less sensitive Ret-Messner small body the researchers concluded that the two identical tiled but heterogeneous A-beta mechanical sensory neurons had different molecular, physiological, and microstructure characteristics that dominated the Messner small body, which is the basis for perceived the slightest detectable force and behavioral response seismosphere (Bio Valley Bioon.com) References: 1 Nicole L Neubarth et Meissner corpuscles and theirs spatially interming led afferents yn llybley gentle touch the Science, 2020, doi: 10.1126/science.abb2751.
2.Kara Marshall et al Getting a grip on touch
Science, 2020, doi: 10.1126/science.abc7610.
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