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March 20, 2022 / Bio Valley BIOON / --- Synaptic plasticity is the process by which neurons adjust the strength of their thousands of inputs, allowing animals to adapt to their environment
In a new study, to test whether the ICR is involved in experience-dependent plasticity, researchers from Columbia University focused on pyramidal neurons of hippocampal area CA1 (CA1PN)
As animals explore a new environment, CA1PN integrates these inputs to form spatially tuned receptive fields, also known as place fields, which appear as neurons when an animal occupies a specific location discharge
The ICR shapes receptive fields important for spatial navigation
Based on this, these authors used CA1PN and BTSP as model systems to test whether ICR is involved in the emergence of experience-dependent feature selectivity
The gene Pdzd8 encodes a recently discovered endoplasmic reticulum-mitochondrial junction protein that, when knocked out, results in unrestricted ICR
Taken together, the ICR plays a key previously undescribed role in shaping the dendritic integration properties of CA1PN during the emergence of feature selectivity
References:
Justin K.
