Science: reveal how human cells perceive cancer cells!

June 10, 2019 / BIOON / - new insights on how cells alert the body when they are at risk of cancer may open new doors for the search for treatment When immune cells are under pressure or in danger, they can signal a warning And scientists have found that normal cells also have this characteristic of immune cells This mechanism is part of the human body's system of removing aging cells and is a natural part of the aging process, which is called aging Image source: science advanced researchers say the system can also help the body detect cancer cells more quickly so that they can be removed before they form Aging prevents cell division and the growth of damaged cells This process is caused by the pressure on the cells When a gene with carcinogenic potential becomes active, it can also be triggered Researchers at the University of Edinburgh found that TLR2 and TLR10, key immune molecules in cells, can detect when oncogenes are activated This triggers a series of chemical signals that lead to inflammation and trigger immune cells to clear damaged cells TLR2 and TLR10 are thought to be important for the detection of bacterial and viral infections, but this is the first time they have been found to play a key role in the aging process of ordinary cells The study, published in the journal science advances, was conducted at the University of Edinburgh cancer research center in Edinburgh, UK Dr Juan Carlos Acosta, CRUK career development researcher at the University of Edinburgh, said: "the results of this study expand our understanding of the molecular mechanism of aging control and may lead to new strategies for the development of anti-cancer and anti-aging therapies based on innate immune receptor regulation "Damaged cancer cells age and are killed by the body's own immune system," said Dr Matthew Hoare, a clinical scientist and honorary consultant at the Cambridge Cancer Institute in the UK However, if the immune system does not destroy the aging cells, the surrounding tissues will become inflamed and promote the development of cancer "This is a very hot area of research, because aging may prevent the development of cancer at an early stage These findings indicate for the first time that damaged cancer cells use TLR2 / 10 signal transduction to inflame, presenting potential drug targets that can help the body clear aging cells before they cause harm "Reference: Juan Carlos Acosta et al The inherent immune sensor toll like receiver 2 controls the perception associated secret cryptotype" science advances (2019) Doi: 10.1126/sciadv.aaw0254