Science: researchers find a highly effective antibiotic in the gut

October 22, 2019 / BIOON / -- at present, a major public health challenge is the resurgence of microbial infection caused by multi drug resistant strains Therefore, it is urgent to develop new antibacterial molecules In this case, human intestinal flora is a potential treasure house of untapped valuable natural molecules, such as ribosome synthesis and post-translational modified peptides (ripps) However, the biological activity of ripps, a subclass of sactiptide, is still unclear Photo source: Science advantages and recently a research team led by researchers from the University of Grenoble Alps has found an antibacterial sactiteptide, ruminococcin C1, a compound purified from the cecal contents of rats, which is related to human symbiotic ruminal coccus E1 The researchers found that its heterologous expression and post translation maturity involved a specific sactisynthase to establish a thioether network, which resulted in double hairpin folding Through further experiments, the researchers found that the original structure was active to Clostridium and multidrug-resistant strains, but not toxic to eukaryotic cells Therefore, the researchers believe that Ruminococcin C is a valuable drug development candidate, and its production strain R gnavus E1 is a related probiotic to promote intestinal health Reference: Steve chiemento et al R uminococcin C, a promising innovative procedure by a human gut symbol Science advances 25 SEP 2019: Vol 5, No 9, eaaw9969 doi: 10.1126/sciadv.aaw9969