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By stacking a large pile of stones closely on top of each other, we can get a tight stone wall
But we know that the immune cells in our bodies are not immune to it
To study this process, a team led by Professor Daria E.
During early embryonic development in Drosophila, macrophages follow signaling molecules that guide them to the junction of the embryonic ectoderm and mesoderm
▲ Macrophages (magenta) migrate in a Drosophila embryo, blue dots indicate embryonic cells about to divide (Credit: Maria Akhmanova)
Tracking this process under a high-resolution microscope, Prof.
For the leading macrophages, this is exactly the breakthrough it was expecting
For the researchers, there is still a problem that has not been explained: Is it the morphological change of the cells or the weakening of cell connections that really allows the macrophages to enter?
To address this, they used optogenetics to induce genetic changes related to cell morphology and cell connectivity, respectively
▲ When the macrophages enter, the ectoderm cells in front of them turn round (Image source: Maria Akhmanova)
In a recent study, Prof.
The mechanism by which macrophages enter tissues may also be critical for other types of immune cells
Note: The original text has been deleted
References:
[1] Maria Akhmanova et al.
[2] Dividing walls: How immune cells enter tissue.
