Science: new research reveals that mouse cerebellum is very different from human cerebellum

October 20, 2019 / Biovalley BIOON / - -- in a new study on the brain, researchers from the United States, Italy, the United Kingdom, France and Israel found that mouse cerebellum may not be a good model for human cerebellum The relevant research results were published online in the journal Science on October 17, 2019 The paper title is "spatial expansion of primary generator zones in the developing human cerebellum" They described their comparative study of cerebellar development in humans, mice, and macaques The picture is from cc0 public domain Previous studies have shown that mouse cerebellum and human cerebellum are similar enough, so experiments on mouse cerebellum can be used to learn more about how human cerebellum functions The human cerebellum is part of the brain that processes and responds to sensory information In this new study, the researchers are trying to find out whether mouse cerebellum is really enough like human cerebellum to make the results of such experiments useful to humans The new study involves a very close study of the development of small and medium brains in mice, humans and macaques, another animal used in cerebellar research The researchers compared human cerebellar tissue samples from hospitals and other institutions, cerebellar tissue samples from mice in the study, and cerebellar tissue images from macaques from previous studies They found they had enough material and data to compare cerebellar development from 30 days after conception to about 9 months after birth The researchers reported that they found a completely unexpected difference - a group of progenitor cells that had never been seen in the human cerebellum, mouse or macaque brains before Prior to this discovery, only such groups of cells were seen in the human cerebral cortex They also found that some of the progenitors in an area called rhombic lip are the source of cerebellar granule neurons They found that lip development in humans took longer than in mice and macaques - it continued to mature throughout pregnancy They believe that these obvious differences may mean that the comparison of mouse and human cerebellum may not be as enlightening as people hope They also pointed out that this difference may also explain why it is difficult to model human brain defects in animal models (bio Com) reference: 1 Parthiv haldipur et al Spatiotemporal expansion of primary producer zones in the developing human cerebellum Science, 2019, DOI: 10.1126/science.aax7526 2 Study shows mouse cerebellum quite different from human https://mediaexpress.com/news/2019-10-mouse-cerebellum-human.html