Science: New findings that exercise can prevent brain aging, can not exercise also?

!---- Introduction: There are aging starters and anti-aging starters in the human brain, which play an important role in the aging mechanismthe aging changeof of the brain is the earliest and most important manifestation of the body's agingtherefore, to delay aging should start with preventing brain agingit is well known that exercise prevents aging in the brain, and a recent study published by American scientists suggests that a liver protein can replace exercise as a weapon against aging in the braina new study in mice by scientists at the University of California, San Francisco,""s Eli and Edythe Center for Regenerative Medicine and Stem Cell Research,, suggests that a rarely studied liver protein may be known to be a good cause for the aging brainthe discovery could lead to new treatments that provide neuroprotective effects on physical activity for those who are unable to exercise due to physical limitationsexercise is one of the best studies and the most powerful ways to protect the brain from age-related cognitive decline, and has been shown to improve individual cognitive abilities at risk of neurodegenerative diseases such as Alzheimer's disease and frontal lobe, which inevitably lead to dementia, even for those with rare genetic variantsbut many older people are unable to exercise regularly because of physical limitations or disabilities, and researchers have long been looking for treatments that can bring the same neurological benefits to people with low levels of physical activitya new study published July 9, 2020 in the journal Science, showed that after the mice exercised, their livers secrete a protein called Gpld1 into the bloodstreamin the blood of older mice, the level of this protein corresponds to improved cognitive functionstudy in collaboration with the Center for Memory and Aging at the University of California, San Francisco, found that older people who exercised regularly also had higher levels of the enzyme in their bloodbut researchers have shown that simply increasing the amount of Gpld1 produced by the liver of mice can bring the same benefits to the brain as regular exercise"If there's a drug that has the same benefits to the brain as exercise, everyone takes it," said DrSaul Villeda, an assistant professor in the Department of Anatomy, Physiotherapy and Rehabilitation at the University of California, San Francisco,Now our research suggests that at least some of these benefits may one day come in the form of pills" Villeda's lab has previously shown that biological factors present in the blood of young mice can rejuvenate the brains of aging mice, whereas the factors in the blood of older mice can cause premature age-related cognitive decline in young mice these previous findings prompted Dr Alana Horowitz, a graduate student at the Villeda Laboratory, and Dr Xuelai Fanlai, a postdoctoral researcher, to study factors that may also have exercise benefits in the blood, which are also thought to rejuvenate the aging brain in a manner similar to the lab's "young blood" experiment Horowitz and Fan took blood from older mice who had exercised regularly for seven weeks and injected them into sedentary mice they found that after four weeks of treatment, older mice had significantly improved learning and memory skills, similar to those in mice who exercised regularly when they examined the brains of the animals, they found evidence of increased neurons in the hippocampus, an indicator of strong exercise that gives people life to find out which specific biological factors in the blood may be behind these effects, Horowitz, Fan and his colleagues measured the amounts of different soluble proteins in the blood of active and inactive mice they identified 30 candidate proteins, and to their surprise, 19 of them came mainly from the liver, and many of them were previously associated with the function of controlling the body's metabolism two of these proteins, Gpld1 and pon1, are particularly important for metabolic processes, and researchers have chosen to study Gpld1 in more detail because few previous studies have studied the function of Gpld1 team found that gpld1 increased in blood circulation after exercise in mice, and that Gpld1 levels were associated with increased cognitive ability in mice analyzed human data collected by the Hillblom Aging Network at the University of California, San Francisco's Center for Memory and Aging, and found that healthy, active older people also had higher levels of Gpld1 in their blood than less active older adults to test whether Gpld1 itself can drive the observed benefits of exercise, the researchers used genetic engineering to induce the livers of older mice to produce excess Gpld1, and then measured the performance of these mice in multiple tests on cognitive and memory aspects to their surprise, the three-week treatment produced a similar effect to six weeks of regular exercise, and the growth of new neurons in the hippocampus increased significantly further laboratory tests showthat gpld1 produced by the liver does not protect the brain from toxic or infectious substances in the blood through the so-called blood-brain barrier , the protein appears to affect the brain by reducing inflammation and blood clotting in the body coagulation and inflammation increase with age and are associated with dementia and age-related cognitive decline the lab is currently working to better understand how Gpld1 interacts with other biochemical signaling systems to produce its brain-promoting mechanisms, hoping to identify specific targets for treatmentthates that will one day bring many protective effects to the aging brain .