Science: new discovery! Scientists identify special receptors in the brain that are associated with negative emotions!

November 14, 2019 / BIOON / - recently, in a research report published in the international journal Science, scientists from the University of Sydney and other institutions identified a special brain receptor in the brain that is believed to be associated with negative emotions through research, and relevant research results are expected to help develop new targeted therapies Source: cc0 public domain researchers say that this special brain receptor can effectively regulate the body's negative emotions (negative emotions) This pea sized receptor is located in a rarely studied area of the brain, the medial habenular region Habenula), which plays a key role in regulating negative emotions, is called glycine gated NMDA receptor At present, researchers do not know the function of medial habenular nucleus in the brain, but it is directly related to the negative motivation state We all know that glun3a subunits in the medial habenular nucleus of adults and NMDA receptor formed from these subunits are likely to have different characteristics, and we do not expect to find the receptor we want to find; normally, NMDA receptor needs two different neurotransmitter molecules to bind and activate the receptor, namely glutamate and glycine The researchers found that only one neurotransmitter is needed to activate the receptor, which is glycine Receptor can command the function of brain, and it is also the target of 40% drugs at present Therefore, in this paper, the role of this rare receptor discovery machine in regulating anxiety disorder and the effect on individual negative experience means that it may be a highly specific target for the development of mood regulating drugs Psychoactive drugs usually have certain side effects, because they do not have particularity and affect the whole brain function The discovery of this new receptor may help researchers to develop drugs with smaller side effects and more targeted The results of this study are also of great significance for future researchers to develop new drugs In later research, researchers will continue to deepen Research and understand the function of this newly discovered receptor, and finally develop drugs that can effectively improve mental health and body pain Origin: y Otsu, e darcq, K pietrajtis, et al Control of avoidance by glycine gated glun1 / glun3a NMDA receivers in the Advisory media habenula, Science (2019) Doi: 10.1126/science.aax1522