Science|。 New concept: a systematic review of the treatment of cancer when refined

Circadian rhythms coordinate the daily rhythms of a person's biophysic, physiological, and behavioral functions.
in each case, the loss of circadian rhythms leads to a reduced chance of survival.
this leads to the assumption that circadian rhythm disorders can lead to disease.
January 1, 2021, Aziz Sancar of the University of North Carolina and others published a review article on Science Online entitled "Clocks, cancer, and chronochemotherapy", which reviews the effects of clock interruptions on human health, especially the carcinogenic effects, and research efforts to improve cancer treatment through time-based therapy.
certain areas of the field are maturing, which may reveal treatment pathways.
DNA removal and repair plays an important role in the development of UV-induced skin cancer, as well as in the functioning of Pt-based chemotherapy drugs.
repair has a very strong circadian rhythm regulation, and its activity stage depends primarily on the transcription rhythm of a single gene in a given tissue (although the entire system also has an internal rhythm).
that other insights into tumors and mechanisms may also make progress in treatment in the foreseeable future.
circadian rhythms are inherent in biochemical, physiological and behavioral functions of organisms that oscillate during periods of up to 24 hours, which is an almost universal feature of the ubiquitous nature of the ubiquitous organism.
the universality of the biological clock in most life forms strongly suggests that it must give choice an advantage.
in each case, the loss of circadian rhythms leads to a reduced chance of survival.
this leads to the assumption that circadian rhythm disorders can lead to disease.
here, the reviews the effects of clock breaks on human health, particularly carcinogenic effects, and the status of research efforts to improve cancer treatment through time-based treatment.
at the molecular level consists of a delayed transcription-translation feedback loop (TTFL).
BMAL1 and CLOCK (or its side-by-side ant NPAS2) form the activation arm, and the cryptin proteins (CRY1 and CRY2) and PER (PER1, PER2 and possibly PER3) form the deterrent arm of the TTFL.
this major TTFL is consolidated by a secondary ring consisting of an orphaned α (RORA) associated with the nuclear-α-ERB alpha and respoloric acid.
chromatin composition, histone acetylation and RNA polymerase II combine to produce circadian rhythms that give many genes a transcriptional rhythm of circadian rhythms.
in humans and mice, 50-80% of protein-coding genes are clock-controlled.
, in turn, genes that regulate circadian rhythms include genes that are critical to the timing of cell division, which can lead to strong rhythms of tissue division.
, circadian rhythm disorders can lead to cell division disorders, a sign of cancer.
tumor occurrence is obviously affected by circadian rhythm mechanism, but does not support the hypothesis that circadian rhythm clock gene is a general tumor suppressor.
the pathogenic significance of clock gene disorders in tumors is not entirely clear.
example of circadian rhythm control for
DNA nucleotide removal repair illustrates the challenge of clinically developing the interaction between clock and cancer, as the circadian rhythm susceptible phase of each gene changes according to its potential transcription rhythm.
the concept of timing therapy is attractive, the complexity of clock-cancer interactions makes predicting the effects of timed dosing challenging.
with the increase in the specificity of chemotherapy agents, the specific interaction between circadian rhythm mechanisms and therapeutic targets can be better understood and optimized.
the past 25 years, great progress has been made in understanding the molecular mechanisms of circadian rhythms and cancer.
, a number of attempts have been made to use biological clocks to guide cancer prevention and treatment.
, despite these efforts, the relationship between the clock and cancer is still difficult to simplify.
therefore, the early generalizations of the effects of clock interruptions promoting improved circadian rhythms in cancer or chemotherapy have been replaced by a more realistic view that the link between clocks and cancer is highly specific.
clock mechanism affects cancer, which in turn destroys specific clock mechanisms.
certain areas of the field are maturing, which may reveal treatment pathways.
DNA removal and repair plays a vital role in the development of UV-induced skin cancer and is critical to the functioning of Pt-based chemotherapy drugs.
repair has a very strong circadian rhythm regulation, and its activity stage depends primarily on the transcription rhythm of a single gene in a given tissue (although the entire system also has an internal rhythm).
that other insights into tumors and mechanisms may also make progress in treatment in the foreseeable future.
。