-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
Figure: Macrophages attack adrenal tumors
in male mice.
Why is adrenal cancer1 more common in women? Why is their prognosis worse?
A team of scientists led by CNRS researchers answered these questions in an article published on October 14, 2022 by scientific advancement.
They showed that in male mice, more immune cells called macrophages were recruited, which can destroy tumor cells
.
Thus, aggressive tumor progression is rarely seen in male mice; In female cells, macrophages cannot slow down the growth of tumors, which eventually metastasize
.
Through molecular analysis, the team determined that recruiting anti-tumor macrophages relies on testosterone
.
After simply injecting this hormone into females, macrophages capable of destroying tumor cells are summoned to fight
.
Building on these findings, the scientists conducted another study with human data that revealed the same difference
in macrophage recruitment rates between men and women in adrenal cancer patients.
This finding suggests that hormonal stimulation has the potential as a treatment for this cancer, which has a 5-year survival rate of less than 30 percent
.
essay
Sexually dimorphic activation of innate antitumour immunity prevents adrenocortical carcinoma development
